质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
O=C1OC(C(C2=CC3=C(S2)C=CC=C3)=C1Br)O
生化/生理作用
CAY10526 is a selective inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) expression. CAY10526 potently inhibits PGE2 production in lipopolysaccharide-stimulated RAW 264.7 cells. CAY10526 significantly suppressed tumor growth and increased apoptosis in melanoma xenografts.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Darren J Perkins et al.
Nature immunology, 19(12), 1309-1318 (2018-11-07)
The unique cell biology of Toll-like receptor 4 (TLR4) allows it to initiate two signal-transduction cascades: a signal dependent on the adaptors TIRAP (Mal) and MyD88 that begins at the cell surface and regulates proinflammatory cytokines, and a signal dependent
Sun-Hee Kim et al.
Pigment cell & melanoma research, 29(3), 297-308 (2016-01-24)
COX-2 and its product PGE2 enhance carcinogenesis and tumor progression, which has been previously reported in melanoma. As most COX inhibitors cause much toxicity, the downstream microsomal PGE2 synthase-1 (mPGES1) is a consideration for targeting. Human melanoma TMAs were employed
Maria D Guerrero et al.
Journal of medicinal chemistry, 50(9), 2176-2184 (2007-04-05)
As a part of our drug discovery effort, recently we clarified the molecular basis of phospholipase A2 (PLA2) inactivation by petrosaspongiolide M (PM), an interesting metabolite belonging to a marine sesterterpene family, containing in its structural architecture a gamma-hydroxybutenolide moiety
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