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Merck
CN
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文件

安全信息

SML2519

Sigma-Aldrich

Anamorelin

≥98% (HPLC)

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别名:
2-Amino-N-[(2R)-1-[(3R)-3-benzyl-3-[dimethylamino(methyl)carbamoyl]piperidin-1-yl]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-methylpropanamide, ONO-7643, RC-1291, ST-1291
经验公式（希尔记法）:
C31H42N6O3
CAS号:
249921-19-5
分子量:
546.70
MDL编号:
MFCD11973671
UNSPSC代码:
12352200
NACRES:
NA.77

检测方案

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

储存温度

−20°C

InChI

1S/C31H42N6O3/c1-30(2,32)28(39)34-26(18-23-20-33-25-15-10-9-14-24(23)25)27(38)37-17-11-16-31(21-37,29(40)36(5)35(3)4)19-22-12-7-6-8-13-22/h6-10,12-15,20,26,33H,11,16-19,21,32H2,1-5H3,(H,34,39)/t26-,31-/m1/s1

InChI key

VQPFSIRUEPQQPP-MXBOTTGLSA-N

生化/生理作用

Anamorelin is a non-peptidic ghrelin mimetic and growth hormone (GH) secretagogue. It is an orally-active, brain-penetrant, selective agonist of the ghrelin/growth hormone secretagogue receptor (GHSR). Anamorelin has been shown to increases appetite, overall body weight, lean body mass, and muscle strength in clinical studies with cancer patients suffering from cachexia.

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301

危险分类

Acute Tox. 3 Oral

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Nobuyuki Katakami et al.
Cancer, 124(3), 606-616 (2017-12-06)
Cachexia, described as weight loss (mainly in lean body mass [LBM]) and anorexia, is common in patients with advanced cancer. This study examined the efficacy and safety of anamorelin (ONO-7643), a novel selective ghrelin receptor agonist, in Japanese cancer patients
Palliative care: Anamorelin provides benefit to patients with cachexia.
Peter Sidaway
Nature reviews. Clinical oncology, 15(2), 68-68 (2017-12-20)
S C Gross et al.
Orthopedics, 12(12), 1561-1564 (1989-12-01)
From 1968 to 1987, 22 patients were diagnosed with dysfunctioning digits after complete distal digital amputations. Each patient had the proximal portion of the partially amputated phalanx left within the injured digit. On average, 21 months after the initial injury

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