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Merck
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安全信息

SML2483

Sigma-Aldrich

Fesoterodine fumarate

≥93% (HPLC)

别名:

2-Methylpropanoic acid-2-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl ester, fumarate salt

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About This Item

经验公式（希尔记法）:
C26H37NO3 · C4H4O4
CAS号:
286930-03-8
分子量:
527.65
MDL编号:
MFCD12756004
UNSPSC代码:
12352200
NACRES:
NA.77

方案

≥93% (HPLC)

表单

powder

颜色

white to beige

溶解性

H2O: 2 mg/mL, clear

储存温度

2-8°C

SMILES字符串

O=C(C(C)C)OC1=C([C@@H](C2=CC=CC=C2)CCN(C(C)C)C(C)C)C=C(CO)C=C1.OC(/C=C/C(O)=O)=O

InChI

1S/C26H37NO3.C4H4O4/c1-18(2)26(29)30-25-13-12-21(17-28)16-24(25)23(22-10-8-7-9-11-22)14-15-27(19(3)4)20(5)6;5-3(6)1-2-4(7)8/h7-13,16,18-20,23,28H,14-15,17H2,1-6H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t23-;/m1./s1

InChI key

MWHXMIASLKXGBU-RNCYCKTQSA-N

生化/生理作用

Fesoterodine fumarate is a prodrug of 5-hydroxymethyl tolterodine (5-HMT), which a muscarinic M2 and M3-receptor antagonist with antispasmodic activity, and is also the active metabolite of tolterodine. Fesoterodine fumarate is used clinically for the treatment of overactive bladder (OAB).

象形图

Health hazardExclamation mark
GHS08,GHS07

警示用语：

Warning

危险分类

Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
0000144020
0000144020
0000153000
0000139439

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Xavier Biardeau et al.
PloS one, 12(1), e0169694-e0169694 (2017-01-07)
In spinal cord injury, onset of detrusor overactivity (DO) is detrimental for quality of life (incontinence) and renal risk. Prevention has only been achieved with complex sophisticated electrical neuromodulation techniques. To assess the efficacy of early fesoterodine fumarate (FF) administration
Xavier Gamé et al.
European journal of pharmacology, 833, 155-157 (2018-05-29)
Fesoterodine (as one of three drugs: dutasteride, finasteride and fesoterodine) was classified B (beneficial) by LUTS-FORTA 2014, indicating that it is a medicinal product with proven or obvious efficacy in the elderly, with limited side effects and/or safety concerns. A
Shizuo Yamada et al.
Pharmacology & therapeutics, 189, 130-148 (2018-05-02)
Antimuscarinic agents are now widely used as the pharmacological therapy for overactive bladder (OAB) because neuronal (parasympathetic nerve) and non-neuronal acetylcholine play a significant role for the bladder function. In this review, we will highlight basic and clinical aspects of

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