SML2470
GYY4137 sodium, dichloromethane-free
≥98% (HPLC), H2S donor, powder
别名:
(4-Methoxyphenyl)-4-morpholinyl-phosphinodithioic acid, sodium salt, GYY4137 Na salt, GYY4137 sodium salt, Na-GYY4137, Sodium 4-methoxyphenyl(morpholino)phosphinodithioate, Sodium GYY4137
产品名称
GYY4137 sodium, dichloromethane-free, ≥98% (HPLC)
InChI
1S/C11H16NO2PS2.Na/c1-13-10-2-4-11(5-3-10)15(16,17)12-6-8-14-9-7-12;/h2-5H,6-9H2,1H3,(H,16,17);/q;+1/p-1
InChI key
ZFQXKWOUNSKHAG-UHFFFAOYSA-M
SMILES string
[S-]P(C1=CC=C(C=C1)OC)(N2CCOCC2)=S.[Na+]
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear
shipped in
wet ice
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
GYY4137 sodium (Na-GYY4137) is a dichloromethane-free, water-soluble sodium salt form of the slow-releasing hydrogen sulfide (H2S) donor GYY4137. Na-GYY4137 is devoid of potential off-target effects associated with the use of dichloromethane-complexed GYY4137 morpholine salt form. Morpholine is biologically active and toxic (LD50 range of 300-500 mg/kg in rodents), while dichloromethane is carcinogenic and can metabolize in vivo to carbon monoxide, causing unintended CO-dependent effects.
Water soluble, non-toxic alternative to the dichloromethane-containing morpholine salt form of the hydrogen sulfide (H2S) donor GYY4137.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Investigating the generation of hydrogen sulfide from the phosphonamidodithioate slow-release donor GYY4137
Lehto SG, Weyer AD, Youngblood BD, Zhang M, Yin R, Wang W, Teffera Y, Cooke M, Stucky CL, et al
MedChemComm, 6, 1649-1655 (2015)
Eva Latorre et al.
Aging, 10(7), 1666-1681 (2018-07-22)
Cellular senescence is a key driver of ageing, influenced by age-related changes to the regulation of alternative splicing. Hydrogen sulfide (H2S) has similarly been described to influence senescence, but the pathways by which it accomplishes this are unclear.We assessed the
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