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Merck
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安全信息

SML2438

Sigma-Aldrich

Magnolin

≥95% (HPLC)

别名:

Magnolin, (+)-Magnolin, (1S,3aR,4S,6aR)-1-(3,4-Dimethoxyphenyl)tetrahydro-4-(3,4,5-trimethoxyphenyl)-1H,3H-furo[3,4-c]furan, Medioresinol dimethyl ether, (1S,3aR,4S,6aR)-1-(3,4-Dimethoxyphenyl)tetrahydro-4-(3,4,5-trimethoxyphenyl)-1H,3H-furo[3,4-c]furan

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About This Item

经验公式（希尔记法）:
C23H28O7
CAS号:
31008-18-1
分子量:
416.46
MDL编号:
MFCD07783722
UNSPSC代码:
12352200
NACRES:
NA.77

方案

≥95% (HPLC)

表单

powder

旋光性

[α]/D +46 to +56°, c = 0.5 in chloroform-d

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

储存温度

−20°C

SMILES字符串

[H][C@]12[C@]([C@@H](C3=CC(OC)=C(OC)C(OC)=C3)OC2)([H])CO[C@@H]1C4=CC=C(OC)C(OC)=C4

InChI

1S/C23H28O7/c1-24-17-7-6-13(8-18(17)25-2)21-15-11-30-22(16(15)12-29-21)14-9-19(26-3)23(28-5)20(10-14)27-4/h6-10,15-16,21-22H,11-12H2,1-5H3/t15-,16-,21+,22+/m0/s1

InChI key

MFIHSKBTNZNJIK-RZTYQLBFSA-N

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生化/生理作用

Magnolin is a main component of Magnolia flos the exhibits anti-inflammatory, antioxidative, and vasodilatory activities. Magnolin inhibits cell migration and invasion by targeting the ERKs/RSK2 signaling. Also magnolin protects against renal tubular necrosis, apoptosis, and the deterioration of renal function in contrast-induced nephropathy (CIN) in rats.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000063197
0000063198
0000054640

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Feng Wang et al.
Oxidative medicine and cellular longevity, 2014, 203458-203458 (2014-11-18)
Magnolin is the major active ingredient of the herb Magnolia fargesii which has anti-inflammatory and antioxidative effects. Oxidative stress and apoptosis are involved in the pathogenesis of contrast-induced nephropathy (CIN). We hypothesize that Magnolin could protect against CIN through antioxidative
Yeqing Huang et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 87, 714-720 (2017-01-17)
Magnolin is the most active ingredient in the herb Magnolia fargesii, which has been traditionally used in oriental medicine to treat headaches and nasal congestion. Recent researches demonstrate that Magnolin inhibits cancer cell migration and invasion. This study used cell
Cheol-Jung Lee et al.
BMC cancer, 15, 576-576 (2015-08-09)
Magnolin is a natural compound abundantly found in Magnolia flos, which has been traditionally used in oriental medicine to treat headaches, nasal congestion and anti-inflammatory reactions. Our recent results have demonstrated that magnolin targets the active pockets of ERK1 and

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