检测方案
≥98% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
生化/生理作用
H-151是干扰素基因刺激剂(STING)蛋白的不可逆拮抗剂，STING蛋白是胞质DNA传感通路的中心信号成分。 尽管STING是先天免疫途径的重要组成部分，但它还经证在一些炎症性疾病中具有致病作用。 H-151是一种强效和选择性的STING拮抗剂，在人细胞和小鼠体内都具有抑制活性。 作为预处理的H-151被证明可以减弱小鼠模型中自身炎症性疾病的病理特征，减少接受STING激动剂10-羧甲基-9-吖啶酮(CMA)治疗的小鼠的全身细胞因子反应。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Amir K Varkouhi et al.
Bioconjugate chemistry, 21(12), 2339-2346 (2010-11-06)
N,N,N-Trimethylated chitosan (TMC) is a biodegradable polymer emerging as a promising nonviral vector for nucleic acid and protein delivery. In the present study, we investigated whether the introduction of thiol groups in TMC enhances the extracellular stability of the complexes
J H Hamman et al.
Drug development and industrial pharmacy, 29(2), 161-172 (2003-03-22)
N-trimethyl chitosan chloride (TMC) is a polycation that enhances drug transport across epithelia by opening tight junctions. The degree of quaternization of TMC determines the number of positive charges available on the molecule for interactions with the negatively charged sites
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