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Merck
CN

SML2422

Sigma-Aldrich

槐果碱

≥95% (HPLC)

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别名:
(-)-Sophocarpine, 13,14-Didehydromatridin-15-one, SC
经验公式(希尔记法):
C15H22N2O
CAS号:
分子量:
246.35
MDL编号:
UNSPSC代码:
12352200

生物来源

Sophora alopecuroides

检测方案

≥95% (HPLC)

形式

powder

旋光性

[α]/D -26 to -35°, c = 0.5 in ethanol

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

储存温度

−20°C

InChI

1S/C15H22N2O.BrH/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14;/h1,7,11-13,15H,2-6,8-10H2;1H/t11-,12+,13+,15-;/m0./s1

InChI key

NBBQEIQEBNYSFK-PUILLJIJSA-N

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生化/生理作用

Sophocarpine is a natural product found to have anti-inflammatory, anti-cancer, and antiviral activity. Sophocarpine was active in an mouse xenograft model. It inhibited growth of head and neck squamous cell carcinomas by downregulation of miR-21 expression. Sophocarpine was also shown to protecs mice from a form of hepatitis by inhibiting the IFNg/STAT1 pathway.

象形图

Skull and crossbones

警示用语:

Danger

危险声明

危险分类

Acute Tox. 3 Oral

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

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Genhuan Yang et al.
Annals of palliative medicine, 9(4), 1622-1630 (2020-06-13)
Cigarette smoking is one of the main predisposing factors for atherosclerosis, which can lead to vascular inflammation. Emerging research has demonstrated that the rate of restenosis is increased following angioplasty in smokers. Sophocarpine, one of the Sophora alkaloids, can play

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