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检测方案
≥98% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
−20°C
SMILES字符串
ClC(C=CC=C1Cl)=C1CSC2=NN=C(C3=CC=CN3)O2
生化/生理作用
Dooku1是Yoda1的类似物，是机械敏感的Piezo1通道的有效和选择性拮抗剂，可抑制内源性Yoda1激活的通道。Dooku1抑制Yoda1引起的主动脉松弛的松弛。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Yangmengfan Chen et al.
Journal of functional biomaterials, 14(3) (2023-03-29)
Exposure to extremely low frequency pulsed electromagnetic fields (ELF-PEMF) is supposed to simulate local EMF generated during mechanical stimulation of bone and may therefore be used to improve bone regeneration. This study aimed at optimizing the exposure strategy and investigating
Elizabeth L Evans et al.
British journal of pharmacology, 175(10), 1744-1759 (2018-03-03)
The mechanosensitive Piezo1 channel has important roles in vascular physiology and disease. Yoda1 is a small-molecule agonist, but the pharmacology of these channels is otherwise limited. Yoda1 analogues were generated by synthetic chemistry. Intracellular Ca2+ and Tl+ measurements were made
Florian Labarrade et al.
International journal of cosmetic science, 45(5), 604-611 (2023-05-12)
Throughout our existence, the skin senses and analyses the mechanical forces imposed by the environment. In response to these environmental forces, skin can deform itself and achieve a biological response. The subsequent cutaneous plasticity emerges from mechanical properties arising from
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