所有图片(1)
About This Item
经验公式（希尔记法）:
C19H26O2
CAS号:
分子量:
286.41
Beilstein:
2059239
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
检测方案
≥98% (HPLC)
形式
powder
药品控制
USDEA Schedule III
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
room temp
SMILES字符串
[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)C(=O)CC[C@@]24[H]
InChI
1S/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-16H,3-10H2,1-2H3/t14-,15-,16-,18-,19-/m0/s1
InChI key
AEMFNILZOJDQLW-QAGGRKNESA-N
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生化/生理作用
睾酮前体和具有雄激素活性的代谢物；可增大前列腺癌或胰腺癌的风险。
4-Androstenedione, commonly known as Androstenedione, is an endogenous androgen steroid hormone. 4-Androstenedione functions as an intermediate in the biosynthesis of testosterone, estradiol and estrone. Recent studies indicate that 4-Androstenedione is involved in aromatase inhibitors induce painful musculoskeletal symptoms (AIMSS) by activation of TRPA1.
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Carc. 2 - Lact. - Repr. 1A
WGK
WGK 2
法规信息
监管及禁止进口产品
Francesco De Logu et al.
Cancer research, 76(23), 7024-7035 (2016-10-21)
Aromatase inhibitors (AI) induce painful musculoskeletal symptoms (AIMSS), which are dependent upon the pain transducing receptor TRPA1. However, as the AI concentrations required to engage TRPA1 in mice are higher than those found in the plasma of patients, we hypothesized
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