检测方案
>97% (HPLC)
形式
powder
颜色
white to brown
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
生化/生理作用
Kinesore is a cell penetrant and potent activator of kinesin-1 that induces kinesin light chain tetratricopeptide repeat domain-dependent kinesin-1 activation in the absence of organelle cargo-adaptor engagement. It inhibits kinesin-1 interaction with peptide fragment of organelle-specific cargo adaptors. Kinesore induces kinesin light chain conformational switch that causes remodeling of the microtubule network in cells.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Thomas S Randall et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(52), 13738-13743 (2017-12-13)
The microtubule motor kinesin-1 interacts via its cargo-binding domain with both microtubules and organelles, and hence plays an important role in controlling organelle transport and microtubule dynamics. In the absence of cargo, kinesin-1 is found in an autoinhibited conformation. The
Raeann Goering et al.
eLife, 12 (2023-03-04)
RNA molecules are localized to specific subcellular regions through interactions between RNA regulatory elements and RNA binding proteins (RBPs). Generally, our knowledge of the mechanistic details behind the localization of a given RNA is restricted to a particular cell type.
Yerbol Tagay et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 10(31), e2302229-e2302229 (2023-09-20)
The principal cause of death in cancer patients is metastasis, which remains an unresolved problem. Conventionally, metastatic dissemination is linked to actomyosin-driven cell locomotion. However, the locomotion of cancer cells often does not strictly line up with the measured actomyosin
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