SML2346
Ganciclovir
≥99% (HPLC), DMSO solution, viral DNA elongation inhibitor
别名:
更昔洛韦现成溶液, 2-氨基-1,9-二氢-9-[[2-羟基-1-(羟甲基)乙氧基]甲基]-6H-嘌呤-6-酮, 9-(1,3-二羟基-2-丙氧甲基)鸟嘌呤, DHPG
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关于此项目
经验公式（希尔记法）:
C9H13N5O4
化学文摘社编号:
分子量:
255.23
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
更昔洛韦现成溶液, ≥99% (HPLC), 10 mM in DMSO
SMILES string
[n]1(c2[nH]c(n[c](c2nc1)=O)N)COC(CO)CO
InChI
1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17)
InChI key
IRSCQMHQWWYFCW-UHFFFAOYSA-N
assay
≥99% (HPLC)
form
DMSO solution
concentration
10 mM in DMSO
storage temp.
2-8°C
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相关类别
Application
更昔洛韦现成溶液已与白藜芦醇联合使用，以研究其对黑色素瘤细胞的作用。它还被用作病毒胸苷激酶的合成底物，以研究其对人类可诱导多能干细胞的影响。
Biochem/physiol Actions
更昔洛韦是一种核苷鸟苷类似物，含有活性部分更昔洛韦三磷酸。这种活性部分可以通过在延伸过程中中断病毒 DNA 来抑制病毒复制。更昔洛韦是预防人类免疫缺陷病毒（HIV）患者巨细胞病毒（CMV）视网膜炎疾病的有效药物。它对涉及肺、肝和胃肠道的 CMV 疾病具有治疗作用。更昔洛韦可被单纯疱疹病毒胸苷激酶（HSV-TK）或宿主编码的脱氧鸟苷激酶酶促磷酸化为活性三磷酸类似物。 它具有治疗同种异体骨髓、肾脏、心脏、肝脏和肺移植的潜力。
Other Notes
更昔洛韦现成 DMSO 溶液以 10mM 浓度（2.55mg/mL）提供。建议将提供的现成溶液稀释至 2-100μM 的工作浓度，用于细胞培养应用。
signalword
Danger
hcodes
Hazard Classifications
Muta. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 2
flash_point_f
188.6 °F - closed cup
flash_point_c
87 °C - closed cup
A Tseng et al.
The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses, 7(3), 183-194 (1996-05-01)
To review the pharmacology and pharmacokinetics of intravenous, oral and intraocular ganciclovir, and to discuss the role of these various formulations in the management of cytomegalovirus (CMV) retinitis in AIDS patients. A MEDLINE search (1987 through November 1995) of English-language
Targeting of herpes simplex virus 1 thymidine kinase gene sequences into the OCT4 locus of human induced pluripotent stem cells.
Ou, et al.
PLoS ONE, 8, e81131-e81131 (2015)
Yuan Chen et al.
Journal of cancer research and clinical oncology, 146(6), 1489-1499 (2020-04-05)
To investigate the synergistic effect of resveratrol on the bystander effect of TK/GCV suicide gene system in melanoma cells. The effect of resveratrol on the growth of B16 cells and the synergistic effect of resveratrol with or without GCV were
C J Oon et al.
Antiviral research, 41(3), 113-118 (1999-05-13)
Lamivudine is a new antiviral agent effective against hepatitis B viral (HBV) infections but can result in virus-drug resistance associated with mutations in the conserved 'YM552DD' motif of the HBV DNA polymerase. Due to their overlapping coding regions in the
J S Cannon et al.
Journal of virology, 73(6), 4786-4793 (1999-05-11)
Human herpesvirus 8 (HHV-8) sensitivity to the nucleoside analog ganciclovir (GCV) suggests the presence of a virally encoded kinase that catalyzes the initial phosphorylation of GCV. Analysis of the HHV-8 genome identified two candidate kinases: proteins encoded by open reading
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