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Merck
CN
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安全信息

SML2345

Sigma-Aldrich

钩藤碱

≥95% (HPLC)

别名:

(αE,1′R,6′R,7′S,8′aS)-6′-Ethyl-1,2,2′,3′,6′,7′,8′,8′a-octahydro-α-(methoxymethylene)-2-oxo- Spiro[3H-indole-3,1′(5′H)-indolizine]-7′-acetic acid methyl ester, (7β,16E,20α)-16,17-Didehydro-17-methoxy-2-oxo-corynoxan-16-carboxylic acid methyl ester, Mitrinermin, NSC 21731, Rhynchophyllin, Rhyncophylline, Mitrinermine

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About This Item

经验公式（希尔记法）:
C22H28N2O4
CAS号:
76-66-4
分子量:
384.47
MDL编号:
MFCD00221748
UNSPSC代码:
12352200
NACRES:
NA.77

生物来源

Uncaria rhynchophylla

方案

≥95% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear (warmed)

运输

wet ice

储存温度

−20°C

SMILES字符串

N21[C@H]([C@@]3(CC2)c4c(cccc4)NC3=O)C[C@@H]([C@H](C1)CC)\C(=C/OC)\C(=O)OC

InChI

1S/C22H28N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h5-8,13-15,19H,4,9-12H2,1-3H3,(H,23,26)/b16-13+/t14-,15-,19-,22+/m0/s1

InChI key

DAXYUDFNWXHGBE-KAXDATADSA-N

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生化/生理作用

Rhynchophylline is a spirocyclic alkaloid isolated from Uncaria species that exibits numerous pharmacological activities including hypotensive, neuroprotective, anticonvulsive, antiepileptic, antiarrhythmic, anticoagulant, antispasmodic, and sedative. Rhynchophylline modulates voltage-gated K+ (Kv) channel slow inactivation in mouse neuroblastoma N2A cells. Also it acts as noncompetitive antagonists of NMDA receptor channels in Xenopus oocytes.

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H300

危险分类

Acute Tox. 2 Oral

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000181226
0000177106
0000159606
0000159605
0000159606

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Chun-Hsiao Chou et al.
Journal of natural products, 72(5), 830-834 (2009-04-01)
Rhynchophylline (1), a neuroprotective agent isolated from the traditional Chinese medicinal herb Uncaria rhynchophylla, was shown to affect voltage-gated K(+) (Kv) channel slow inactivation in mouse neuroblastoma N2A cells. Extracellular 1 (30 microM) accelerated the slow decay of Kv currents
Hou-Cai Huang et al.
Evidence-based complementary and alternative medicine : eCAM, 2017, 7593027-7593027 (2017-03-30)
Goutengsan, a Chinese herbal formula, potential protection on Alzheimer's disease (AD) has been less reported. In current study, we investigated the protection of Goutengsan on Aβ1-42-induced pheochromocytoma-derived cells (PC12). Furthermore, the components from Goutengsan in rat plasma were identified by
Bao-Yuan Huang et al.
International journal of oncology, 51(1), 257-268 (2017-05-24)
The overexpression of ATP-binding cassette (ABC) transporters is the main cause of cancer multidrug resistance (MDR), which leads to chemotherapy failure. Uncaria alkaloids are the major active components isolated from uncaria, which is a common Chinese herbal medicine. In this

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