SML2319
TAT-Gap19 trifluoroacetate salt
≥95% (HPLC)
别名:
L-Tyrosylglycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-lysyl-L-glutaminyl-L-isoleucyl-L-?-glutamyl-L-isoleucyl-L-lysyl-L-lysyl-L-phenylalanyl-L-lysine trifluoroacetate salt, YGRKKRRQRRRKQIEIKKFK trifluoroacetate salt
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所有图片(1)
About This Item
经验公式（希尔记法）:
C119H212N46O26 · xC2HF3O2
CAS号:
分子量:
2703.25 (free base basis)
UNSPSC代码:
12352200
NACRES:
NA.77
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方案
≥95% (HPLC)
表单
lyophilized powder
颜色
white to off-white
运输
wet ice
储存温度
−20°C
生化/生理作用
TAT-Gap19 is a cell penetrant analog of a connexin 43 (Cx43) hemichannels selective blocker Gap19. TAT-Gap19 inhibits TAT-Gap19 in mice brain without affecting gap junction channels.
cell penetrant analog of a connexin 43 (Cx43) hemichannels selective blocker Gap19
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Paolo Bazzigaluppi et al.
Neurobiology of disease, 101, 1-7 (2016-12-23)
Extracellular potassium concentration, [K+]o, is a major determinant of neuronal excitability. In the healthy brain, [K+]o levels are tightly controlled. During seizures, [K+]o increases up to 15mM and is thought to cause seizures due to its depolarizing effect. Although astrocytes
Verónica Abudara et al.
Frontiers in cellular neuroscience, 8, 306-306 (2014-11-07)
In the brain, astrocytes represent the cellular population that expresses the highest amount of connexins (Cxs). This family of membrane proteins is the molecular constituent of gap junction channels and hemichannels that provide pathways for direct cytoplasm-to-cytoplasm and inside-out exchange
Laura Walrave et al.
Frontiers in cellular neuroscience, 10, 288-288 (2017-01-10)
Astrocytes are active players in higher brain function as they can release gliotransmitters, which are essential for synaptic plasticity. Various mechanisms have been proposed for gliotransmission, including vesicular mechanisms as well as non-vesicular ones, for example by passive diffusion via
Wei Zhang et al.
Behavioral and brain functions : BBF, 19(1), 23-23 (2023-12-19)
As a kind of environmental noise, infrasonic noise has negative effects on various human organs. To date, research has shown that infrasound impairs cognitive function, especially the ability for learning and memory. Previously, we demonstrated that impaired learning and memory
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