推荐产品
产品名称
盐酸氯氮平N-氧化物, ≥98% (HPLC), Water soluble Clozapine N-oxide
生物来源
synthetic
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
溶解性
DMSO: 40 mg/mL
water: 40 mg/mL
运输
ambient
储存温度
2-8°C
SMILES字符串
ClC1=CC2=C(NC(C=CC=C3)=C3C(N4CC[N+]([O-])(C)CC4)=N2)C=C1.[xHCl]
InChI
1S/C18H19ClN4O/c1-23(24)10-8-22(9-11-23)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
InChI key
OGUCZBIQSYYWEF-UHFFFAOYSA-N
一般描述
氯氮平n -氧化物盐酸盐是氯氮平n -氧化物(CNO)的一种水溶性形式(Sigma cat# C0832)。CNO是非典型抗精神病药物氯氮平的一种惰性代谢产物。CNO是设计药物特异激活的化学遗传设计受体(DREADD)中工程Gq蛋白偶联受体(GPCR)配体。DREADD的典型应用是测试，增强神经元和非神经元细胞的神经元放电和激活Gq信号。
通过使用细胞类型特异性启动子驱动DREADD表达可以实现对细胞群体的选择性靶向，并通过重组系统进一步控制该启动子的表达。DREADD对内源性配体的亲和力较低，其组成活性较低，但可能被CNO等合成化合物激活。
低nM浓度的CNO激活了DREADD系统，并调动了细胞内钙。当小鼠和大鼠按推荐剂量（一般为0.1-3 mg/kg）给药时，CNO在药理学和行为学上似乎是惰性的。CNO通常通过注射给药，但也可以混合到食物或饮用水中。
通过使用细胞类型特异性启动子驱动DREADD表达可以实现对细胞群体的选择性靶向，并通过重组系统进一步控制该启动子的表达。DREADD对内源性配体的亲和力较低，其组成活性较低，但可能被CNO等合成化合物激活。
低nM浓度的CNO激活了DREADD系统，并调动了细胞内钙。当小鼠和大鼠按推荐剂量（一般为0.1-3 mg/kg）给药时，CNO在药理学和行为学上似乎是惰性的。CNO通常通过注射给药，但也可以混合到食物或饮用水中。
其他说明
This is not a pharmaceutical grade product.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral - STOT SE 3
靶器官
Central nervous system
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Sixtine Fleury et al.
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Susan M Ferguson et al.
Nature neuroscience, 14(1), 22-24 (2010-12-07)
Dorsal striatum is important for the development of drug addiction; however, a precise understanding of the roles of striatopallidal (indirect) and striatonigral (direct) pathway neurons in regulating behaviors remains elusive. Using viral-mediated expression of an engineered G protein-coupled receptor (hM(4)D)
Jean-Marc Guettier et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(45), 19197-19202 (2009-10-28)
Impaired functioning of pancreatic beta cells is a key hallmark of type 2 diabetes. beta cell function is modulated by the actions of different classes of heterotrimeric G proteins. The functional consequences of activating specific beta cell G protein signaling
Georgia M Alexander et al.
Neuron, 63(1), 27-39 (2009-07-18)
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Hu Zhu et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39(8), 1880-1892 (2014-02-15)
Synaptic consolidation is a process thought to consolidate memory in the brain. Although lesion studies have mainly implicated the hippocampus (HPC) in this process, it is unknown which cell type(s) or regions of the HPC might be essential for synaptic
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