SML2256
D3-βArr
≥98% (HPLC)
别名:
N-(1-Phenylethyl)-2-(1-piperazinyl)-4-quinazolinamine, N-(1-Phenylethyl)-2-(piperazin-1-yl)quinazolin-4-amine
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关于此项目
经验公式（希尔记法）:
C20H23N5
化学文摘社编号:
分子量:
333.43
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
产品名称
D3-βArr, ≥98% (HPLC)
InChI
1S/C20H23N5/c1-15(16-7-3-2-4-8-16)22-19-17-9-5-6-10-18(17)23-20(24-19)25-13-11-21-12-14-25/h2-10,15,21H,11-14H2,1H3,(H,22,23,24)
InChI key
LOGWGZNWEWFTJV-UHFFFAOYSA-N
SMILES string
CC(C1=CC=CC=C1)NC2=NC(N3CCNCC3)=NC4=CC=CC=C42
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
positive allosteric modulator of TSHR (thyrotropin receptor) for β-Arr 1-mediated signaling
D3-βArr is a positive allosteric modulator of TSHR (thyrotropin receptor) for β-Arr 1-mediated signaling that initiates translocation of β-Arr 1 by direct TSHR activation, while showing no agonistic effect on cAMP production. D3-βarr is a positive allosteric modulator for TSH-enhanced osteoblast differentiation.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Susanne Neumann et al.
The Journal of pharmacology and experimental therapeutics, 364(1), 38-45 (2017-11-02)
Recently, we showed that TSH-enhanced differentiation of a human preosteoblast-like cell model involved a β-arrestin 1 (β-Arr 1)-mediated pathway. To study this pathway in more detail, we sought to discover a small molecule ligand that was functionally selective toward human
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