SML2250
BB-Cl-amidine trifluoroacetate salt
≥98% (HPLC)
别名:
N-[(1S)-1-(1H-Benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-[1,1′-biphenyl]-4-carboxamide trifluoroacetate
登录查看公司和协议定价
所有图片(1)
About This Item
经验公式（希尔记法）:
C26H26ClN5O · xC2HF3O2
CAS号:
分子量:
459.97 (free base basis)
UNSPSC代码:
12352200
NACRES:
NA.77
推荐产品
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
−20°C
SMILES字符串
O=C(C1=CC=C(C2=CC=CC=C2)C=C1)N[C@H](C3=NC4=C(N3)C=CC=C4)CCCNC(CCl)=N
生化/生理作用
BB-Cl-amidine is an irreversible pan-protein-arginine deiminase (PAD) inhibitor (kinact/KI in M-1min-1 = 16100/PAD1, 4100/PAD2, 6800/PAD3, 13300/PAD4) with >20-fold increased potency against U2OS osteosarcoma cutlures (viability assay IC50 = 8.8 μM vs >200 μM with Cl-amidine) and longer in vivo half-life (1.75 hrs vs 15 min for Cl-amidine in plasma post injection in mice) than Cl-amidine. BB-Cl-amidine effectively inhibits PMA-induced neutrophils extracellular trap (NET) formation from lupus-prone MRL/lpr mice-derived bone marrow neutrophils in cultures (by 78% and 34% with 20 μM BB-Cl-amidine or Cl-amidine, respectively), while daily s.c. injection (1 mg/kg) is efficacious in ameliorating lupus symptoms in in MRL/lpr mice in vivo.
Irreversible pan-protein-arginine deiminase (PAD) inhibitor with >10-fold increased potency than Cl-amidine both in vitro and in vivo.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Fatemeh Ghari et al.
Science advances, 2(2), e1501257-e1501257 (2016-03-19)
Peptidyl arginine deiminase 4 (PAD4) is a nuclear enzyme that converts arginine residues to citrulline. Although increasingly implicated in inflammatory disease and cancer, the mechanism of action of PAD4 and its functionally relevant pathways remains unclear. E2F transcription factors are
Daniel M Lewallen et al.
ACS chemical biology, 10(11), 2520-2528 (2015-09-12)
Anti-citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid arthritis (RA) and are routinely used for disease diagnosis. Protein citrullination is also increased in cancer and other autoimmune disorders, suggesting that citrullinated proteins may serve as biomarkers for diseases beyond
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门