所有图片(1)
别名:
3-Phenyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazole-4,5-dione 4-[2-(2-thiazolyl)hydrazone]
经验公式（希尔记法）:
C21H14N6OS2
推荐产品
检测方案
≥98% (HPLC)
形式
powder
颜色
red to dark red-brown
溶解性
DMSO: 2 mg/mL, clear (warmed)
储存温度
2-8°C
SMILES字符串
O=C1N(C2=NC(C3=CC=CC=C3)=CS2)N=C(C4=CC=CC=C4)/C1=N\NC5=NC=CS5
生化/生理作用
BTSA1 is orally available, highly specific and potent BAX activator that binds to N-terminal activation site of Bax and induces conformational changes. BTSA1 potently induces apoptosis in leukemia cell lines and patient samples while sparing healthy cells.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Denis E Reyna et al.
Cancer cell, 32(4), 490-505 (2017-10-11)
The BCL-2 family protein BAX is a central mediator of apoptosis. Overexpression of anti-apoptotic BCL-2 proteins contributes to tumor development and resistance to therapy by suppressing BAX and its activators. We report the discovery of BTSA1, a pharmacologically optimized BAX
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门