SML2236
L-012 钠盐
≥98% (HPLC), powder, neurotoxin
别名:
8-氨基-5-氯-2,3-二氢-7-苯基吡啶并[3,4-d]哒嗪-1,4-二酮，钠盐, 8-氨基-5-氯-7-苯基-2,3-二氢吡啶并[3,4-d]哒嗪-1,4-二酮，钠盐, L012
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关于此项目
经验公式（希尔记法）:
C13H8ClN4O2 · Na
化学文摘社编号:
分子量:
310.67
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
L-012 钠盐, ≥98% (HPLC)
SMILES string
[Na+].Clc1nc(c(c3c1c(n[nH][c]3=O)[O-])N)c2ccccc2
InChI
1S/C13H9ClN4O2.Na/c14-11-8-7(12(19)17-18-13(8)20)9(15)10(16-11)6-4-2-1-3-5-6;/h1-5H,15H2,(H,17,19)(H,18,20);/q;+1/p-1
InChI key
IGEUYSJHQQCEFP-UHFFFAOYSA-M
assay
≥98% (HPLC)
form
powder
color
yellow to orange
solubility
H2O: 2 mg/mL, clear
storage temp.
−20°C
相关类别
Application
L-012已被用作生物发光检测的探针，用于测定分离的小鼠肺中的活性氧（ROS）水平。
Biochem/physiol Actions
L-012是鲁米诺类似物，是培养物和动物体内广泛使用的活性氧和氮物质（RONS；ROS & RNS）化学发光（CL）探针。L-012显示出比鲁米诺、光泽精和MCLA显着更高的CL产量和灵敏度。L-012（LumH2）不是直接与超氧阴离子（O2−）反应，而是通过单电子氧化（在H2O2存在下由过氧化物酶催化）转化为LumH·自由基形式，然后与氧气（O2）反应生成O2−和L-012醌（q-Lum）。O2−依次与LumH·自由基反应，最终导致内过氧化物分解以发出发光。在较小的范围内，H2O2也可以与q-Lum反应产生发光。尽管对NADPH氧化酶衍生的RONS不是特异性的，但L-012也通常用于筛选NADPH氧化酶抑制剂。
在培养物和动物体内中广泛使用的活性氧和氮物种（RONS；ROS和RNS）化学发光（CL）探针。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
M Ii et al.
Biochemical and biophysical research communications, 193(2), 540-545 (1993-06-15)
An enhanced chemiluminescence reaction has been incorporated into an enzyme immunoassay (EIA) for human basic fibroblast growth factor (hbFGF). We developed a new luminol derivative, designated L-012 and a new enhancer, 4-(4-hydroxyphenyl)thiazole. Using these compounds, the detection limit of hbFGF
Ning Fan et al.
Experimental eye research, 161, 71-81 (2017-06-13)
Oxidative injuries, such as those related to reactive oxygen species (ROS), have been implicated in various retinal and optic nerve disorders. Many ROS detection methods have been developed. Although widely utilized, many of these methods are useful only in post
Jacek Zielonka et al.
Free radical biology & medicine, 65, 1310-1314 (2013-10-02)
L-012, a luminol-based chemiluminescent (CL) probe, is widely used in vitro and in vivo to detect NADPH oxidase (Nox)-derived superoxide (O2(*-)) and identify Nox inhibitors. Yet understanding of the free radical chemistry of the L-012 probe is still lacking. We
Andreas Daiber et al.
Redox biology, 12, 35-49 (2017-02-18)
Reactive oxygen and nitrogen species (RONS such as H2O2, nitric oxide) confer redox regulation of essential cellular functions (e.g. differentiation, proliferation, migration, apoptosis), initiate and catalyze adaptive stress responses. In contrast, excessive formation of RONS caused by impaired break-down by
Markus Albert et al.
Methods in molecular biology (Clifton, N.J.), 1621, 69-76 (2017-06-02)
The oxidative burst or the production of reactive oxygen species (ROS) is a typical cellular response of both plants and animals to diverse abiotic and biotic stresses. Mainly, the (re-)active oxygen species include the superoxide anion (O2-), hydrogen peroxide (H2O2)
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