product name
1S,3R-RSL 3, ≥98% (HPLC)
检测方案
≥98% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
−20°C
一般描述
Ras-选择性致死小分子3（ (RSL3) ）通过抑制谷胱甘肽过氧化物酶4（GPx4）活性，诱导铁死亡。.RSL3 不仅激活铁死亡，并且通过与GPX4的相互作用，阻止哺乳动物雷帕霉素靶蛋白（mTOR）信号传导途径的活化。在甲状腺癌细胞系中，RSL3 降低细胞活力， 抑制球体形成，干扰体外细胞迁移。
应用
1S,3R-RSL 3已用于：
- 研究其作为谷胱甘肽过氧化物酶4(GPX4)抑制剂，对脑室下区多形性胶质母细胞瘤(GBM)细胞死亡的影响
- 研究其作为GPX4抑制剂和铁死亡诱导剂对小鼠心肌细胞死亡和心功能衰竭的影响
- 在细胞活力检测中作为HT-1080细胞铁死亡诱导剂
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Ryosuke Shintoku et al.
Cancer science, 108(11), 2187-2194 (2017-08-25)
In cancer cells the small compounds erastin and RSL3 promote a novel type of cell death called ferroptosis, which requires iron-dependent accumulation of lipid reactive oxygen species. Here we assessed the contribution of lipid peroxidation activity of lipoxygenases (LOX) to
Nery Jara et al.
Journal of cellular physiology, 236(8), 5801-5817 (2021-01-13)
Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor with a median survival of 14.6 months. GBM is highly resistant to radio- and chemotherapy, and remains without a cure; hence, new treatment strategies are constantly sought. Vitamin C
Wan Seok Yang et al.
Chemistry & biology, 15(3), 234-245 (2008-03-22)
We screened small molecules to identify two compounds, which we named RSL3 and RSL5, that have increased lethality in the presence of oncogenic RAS. Counter screening with biologically active compounds defined aspects of the mechanism of action for RSL3 and
Inactivation of the glutathione peroxidase GPx4 by the ferroptosis-inducing molecule RSL3 requires the adaptor protein 14-3-3?
Vuckovic AM, et al.
Febs Letters (2020)
Enyong Dai et al.
Biochemical and biophysical research communications, 522(2), 415-421 (2019-11-26)
Ferroptosis is a form of regulated cell death that is triggered by iron accumulation and lipid peroxidation. Although plasma membrane injuries represent an important event in cell death, the impact of membrane repair mechanisms on ferroptosis remains unidentified. Here, we
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