SML2233
XMU-MP-1 盐酸盐
≥98% (HPLC)
别名:
4-((5,10-二甲基-6-氧代-6,10-二氢-5H-嘧啶基[5,4-b]噻吩并[3,2-e] [1,4]二氮杂-2-基）氨基）苯磺酰胺盐酸盐, 4-[（6,10-二氢-5,10-二甲基-6-氧代-5H-嘧啶基[5,4-b]噻吩并[3,2-e] [1,4]二氮杂-2-基）氨基苯磺酰胺盐酸盐
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所有图片(1)
About This Item
经验公式（希尔记法）:
C17H16N6O3S2 · xHCl
CAS号:
分子量:
416.48 (free base basis)
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
检测方案
≥98% (HPLC)
形式
powder
储存条件
desiccated
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear (warmed)
储存温度
−20°C
SMILES字符串
CN(C1=CN=C(NC2=CC=C(S(N)(=O)=O)C=C2)N=C1N(C)C3=C4SC=C3)C4=O
生化/生理作用
XMU-MP-1 以可逆性和 ATP 竞争性的方式抑制 MST 激酶活性（IC50 = 9.8 nM/MST1、18.2 nM/MST2、44.8 nM/MST3、27.3 nM/MST4）（MST1 IC50/[ATP] = 164 nM/10 μM 和 4036 nM/300 μM；MST2 IC50/[ATP] = 34 nM/10 μM 和 1498 nM/300 μM），在 468 个样本组中仅对 17 种其他激酶表现出显著的亲和力和/或抑制力。XMU-MP-1 在人和鼠细胞（有效浓度为 1 μM）中选择性抑制 H2O2 刺激的 MST 自磷酸化和内源 MST1/2 底物（MOB1、LATS、YAP）的磷酸化，但不抑制 JNK 的磷酸化，有效地上调了 YAP 核定位并保护 HepG2 细胞（3 μM）免受 MST2 过表达诱导的细胞死亡。XMU-MP-1 在各种鼠模型（1-3 mg/kg/天，腹腔注射）和大鼠口服中均表现出对体内肝脏和肠道修复和再生的功效（t1/2 = 5.18 h，Tmax = 3 h，AUC = 993 ng•h/mL，F = 39.48％；10 mg/mL，口服）
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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