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SML2210

Sigma-Aldrich

AubipyOMe

≥97% (NMR)

别名:

(SP-4-2)-dichloro(4,4′-dimethoxy-2,2′-bipyridine-kN1,kN1′)-Gold(1+), hexafluorophosphate(1-), [Au(4,4′-dimethoxy-2,2′-bipyridine)Cl2][PF6]

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About This Item

经验公式（希尔记法）:
C12H12AuCl2N2O2 · PF6
CAS号:
1221591-26-9
分子量:
629.07
UNSPSC代码:
12352200
NACRES:
NA.77

方案

≥97% (NMR)

表单

powder

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

储存温度

2-8°C

SMILES字符串

[Cl-][Au+3]1([N]2=C(C=C(C=C2)OC)C3=[N]1C=CC(OC)=C3)[Cl-].F[P-](F)(F)(F)(F)F

生化/生理作用

AubipyOMe is a potent inhibitor of tartrate resistant acid phosphatase (TRAP/ACP5), a metalloenzyme expressed in activated osteoclasts and in macrophages. AubipyOMe exhibited IC50 values of 1.3 μM for TRAP5a and 1.8 μM for TRAP5b and inhibited TRAP activity in murine macrophage and human lung tissue extracts.
Tartrate resistant acid phosphatase (TRAP/ACP5) inhibitor

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000201804
0000201803
0000201804
0000201803
0000132391

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Shujun Yang et al.
Molecular medicine (Cambridge, Mass.), 30(1), 89-89 (2024-06-16)
Myocardial infarction (MI) leads to enhanced activity of cardiac fibroblasts (CFs) and abnormal deposition of extracellular matrix proteins, resulting in cardiac fibrosis. Tartrate-resistant acid phosphatase 5 (ACP5) has been shown to promote cell proliferation and phenotypic transition. However, it remains
Carian E Boorsma et al.
Scientific reports, 7(1), 12570-12570 (2017-10-05)
The enzyme tartrate resistant acid phosphatase (TRAP, two isoforms 5a and 5b) is highly expressed in alveolar macrophages, but its function there is unclear and potent selective inhibitors of TRAP are required to assess functional aspects of the protein. We

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