所有图片(1)
别名:
CID 16016685, N-Butyl-N′-(10,11-dihydro-10-methyl-11-oxodibenzo[b,f][1,4]thiazepin-8-yl)urea
经验公式（希尔记法）:
C19H21N3O2S
推荐产品
检测方案
≥98% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
−20°C
SMILES字符串
CN1C(C(C=CC=C2)=C2SC3=C1C=C(NC(NCCCC)=O)C=C3)=O
生化/生理作用
SR-4995 is a potent and selective ligand of α-β-hydrolase domain containing 5 (ABHD5) that activates adipose triglyceride lipase (ATGL) by dissociating ABHD5 from its inhibitory regulator, perilipin-1 (PLIN1) and PLIN5. SR-4995 directly binds to ABHD5 and prevents ABHD5 to PLIN1. SR-4995 induces lipolysis in adipocytes and muscle, avoiding PKA-dependent signaling.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Matthew A Sanders et al.
Cell metabolism, 22(5), 851-860 (2015-09-29)
Fat and muscle lipolysis involves functional interactions of adipose triglyceride lipase (ATGL), α-β hydrolase domain-containing protein 5 (ABHD5), and tissue-specific perilipins 1 and 5 (PLIN1 and PLIN5). ABHD5 potently activates ATGL, but this lipase-promoting activity is suppressed when ABHD5 is
Elizabeth A Rondini et al.
The Journal of pharmacology and experimental therapeutics, 363(3), 367-376 (2017-09-21)
Current knowledge regarding acute regulation of adipocyte lipolysis is largely based on receptor-mediated activation or inhibition of pathways that influence intracellular levels of cAMP, thereby affecting protein kinase A (PKA) activity. We recently identified synthetic ligands of α-β-hydrolase domain containing
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