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检测方案
≥98% (HPLC)
形式
powder
颜色
yellow to orange
溶解性
DMSO: 2 mg/mL, clear (warmed)
储存温度
−20°C
SMILES字符串
OC1=C2C(C=CC=C2)=C3C(N=C(C=CC=C4)C4=N3)=C1
生化/生理作用
sAJM589 is a Myc inhibitor that disrupts the Myc-Max heterodimer with an IC50 value of 1.8 μM. sAJM589 was shown to suppress cellular proliferation in a variety of MYC-dependent cancer cell line including strong inhibition of Burkitt lymphoma Raji cell line growth. The mechanism of action of sAJM589 is thought to involve increased ubiquitination of Myc by inhibition of Max binding to Myc, leading to proteasome-mediated degradation.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Seung H Choi et al.
ACS chemical biology, 12(11), 2715-2719 (2017-10-05)
Myc plays important roles in cell cycle progression, cell growth, and stem cell self-renewal. Although dysregulation of Myc expression is a hallmark of human cancers, there is no Myc targeted therapy yet. Here, we report sAJM589, a novel small molecule
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