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Merck
CN

SML2162

Telithromycin

≥90% (HPLC), bacterial protein synthesis inhibitor, powder

别名:

(3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-Ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]-10-[[3,4,6-trideoxy-3-dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-2H-oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone

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关于此项目

经验公式（希尔记法）:
C43H65N5O10
化学文摘社编号:
191114-48-4
分子量:
812.00
NACRES:
NA.77
UNSPSC Code:
12352200
EC Number:
682-750-4
MDL number:
MFCD00943561

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产品名称

Telithromycin, ≥90% (HPLC)

InChI key

LJVAJPDWBABPEJ-PNUFFHFMSA-N

InChI

1S/C43H65N5O10/c1-12-33-43(8)37(48(41(53)58-43)19-14-13-18-47-23-31(45-24-47)30-16-15-17-44-22-30)27(4)34(49)25(2)21-42(7,54-11)38(28(5)35(50)29(6)39(52)56-33)57-40-36(51)32(46(9)10)20-26(3)55-40/h15-17,22-29,32-33,36-38,40,51H,12-14,18-21H2,1-11H3/t25-,26-,27+,28+,29-,32+,33-,36-,37-,38-,40+,42-,43-/m1/s1

SMILES string

O=C(N1CCCCN2C=NC(C3=CC=CN=C3)=C2)O[C@]4([C@@]1([H])[C@H](C([C@@H](C[C@]([C@@H]([C@H](C([C@H](C(O[C@@H]4CC)=O)C)=O)C)O[C@H]5[C@@H]([C@H](C[C@H](O5)C)N(C)C)O)(OC)C)C)=O)C)C

assay

≥90% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

相关类别

Biochem/physiol Actions

Ketolide antibiotic
Telithromycin is a ketolide antibiotic, the first to enter clinical use. It is used to treat mild to moderate respiratory infections. Telithromycin binds to the subunit 50S of the bacterial ribosome, interfering with bacterial protein synthesis.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H370

Hazard Classifications

STOT SE 1

target_organs

Liver,Eyes

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

涉药品监管产品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000518935
0000518935
0000457246
0000457245
0000457245

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Pulkit Gupta et al.
Nature chemical biology, 12(3), 153-158 (2016-01-05)
Regulation of gene expression in response to the changing environment is critical for cell survival. For instance, binding of macrolide antibiotics to the ribosome promotes translation arrest at the leader open reading frames ermCL and ermBL, which is necessary for
Marema Makgatho et al.
African health sciences, 15(4), 1271-1276 (2016-03-10)
Malaria is on the increase due to emergence of parasite drug resistance and there is thus an urgent need for the development of new antiparasitic drugs effective at low concentrations. Ketolides antibiotics are used for treatment of various ailments and
George G Zhanel et al.
Therapeutics and clinical risk management, 2(1), 59-75 (2008-03-25)
Acute bacterial sinusitis (ABS), acute exacerbations of chronic bronchitis (AECB), and community-acquired pneumonia (CAP) are common conditions and constitute a substantial socioeconomic burden. The ketolides are a new class of antibacterials with a targeted spectrum of antibacterial activity. In vitro

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