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Merck
CN

SML2156

Sigma-Aldrich

埃罗替尼 盐酸盐

≥98% (HPLC)

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别名:
774 盐酸盐, CP-358, N-(3-乙炔基苯基)-6,7-双(2-甲氧基乙氧基)喹唑啉-4-胺, OSI-744 盐酸盐
经验公式(希尔记法):
C22H23N3O4 · HCl
分子量:
429.90
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77

检测方案

≥98% (HPLC)

形式

powder

储存条件

desiccated

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear (warmed)

储存温度

−20°C

InChI

1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25);1H

InChI key

GTTBEUCJPZQMDZ-UHFFFAOYSA-N

相关类别

一般描述

盐酸厄洛替尼是一种抗肿瘤药物。它调节雷帕霉素(mTOR)抑制的机制靶点、表皮生长因子受体下调和表皮间质转化(EMT)抑制。

应用

盐酸厄洛替尼已被用于激活人 PANC-1 胰腺癌细胞系中的线粒体片段化。

生化/生理作用

盐酸埃罗替尼是受体酪氨酸激酶 EGFR(表皮生长因子受体)的抑制剂。它在临床上用于治疗非小细胞肺癌(NSCLC)和联合治疗转移性胰腺癌。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Rabea Oberthür et al.
Cancer letters, 407, 93-105 (2017-08-22)
Overexpression and activation of receptor tyrosine kinases (RTKs), such as the insulin-like growth factor 1 receptor (IGF1R) and the epidermal growth factor receptor (EGFR), are frequent phenomena in colorectal cancer (CRC). Here, we evaluated the effect and the cellular mechanisms
J D Moyer et al.
Cancer research, 57(21), 4838-4848 (1997-11-14)
The epidermal growth factor receptor (EGFR) is overexpressed in a significant percentage of carcinomas and contributes to the malignant phenotype. CP-358,774 is a directly acting inhibitor of human EGFR tyrosine kinase with an IC50 of 2 nM and reduces EGFR
Kandasamy Saravanakumar et al.
Carbohydrate polymers, 245, 116407-116407 (2020-07-29)
The present work was developed the pH dependent-aptamer AS1411 (APT) decorated and erlotinib (En) loaded chitosan nanoparticles (CSNPs) for promising non-small-cell lung carcinoma (NSCLC) treatment. The characterization studies revealed that formulated APT-En-CSNPs were spherical in shape with size of 165.95
Analytical Methods for Therapeutic Drug Monitoring and Toxicology (2011)
Excessive mitochondrial fragmentation triggered by erlotinib promotes pancreatic cancer PANC-1 cell apoptosis via activating the mROS-HtrA2/Omi pathways
Wan J, et al.
Cancer Cell International, 18(1), 165-165 (2018)

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