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Merck
CN

SML2146

Sigma-Aldrich

马来酸盐 SR-18292

≥98% (HPLC)

别名:

马来酸盐 SR-18292, 1-[(1,1-二甲基乙基)[(4-甲基苯基)甲基]氨基] -3-(1H-吲哚-4-基氧基)-2-丙醇马来酸酯, SR 18292, SR 18292马来酸酯

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About This Item

经验公式(希尔记法):
C23H30N2O2 · C4H4O4
分子量:
482.57
UNSPSC代码:
12352200
NACRES:
NA.77

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

储存温度

2-8°C

SMILES字符串

CC(C)(C)N(CC(O)COC1=CC=CC2=C1C=CN2)CC3=CC=C(C)C=C3.O=C(O)/C=C\C(O)=O

InChI key

CMTOYDGVFTZNSM-BTJKTKAUSA-N

应用

SR-18292马来酸盐已作为过氧化物酶体增殖物激活受体γ共激活因子1α (PGC1α) 的抑制剂,用于研究吡格列酮对脱髓鞘轴突的保护作用。

生化/生理作用

SR-18292是一种可通过PGC-1α乙酰化作用的增强以及糖原异生基因表达的抑制而成为一种有效的特异性肝糖异生抑制剂。SR-18292可在T2D小鼠模型中降低血糖并提高肝胰岛素敏感性。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Mitophagy involves the selective elimination of defective mitochondria during chemotherapeutic stress to maintain mitochondrial homeostasis and sustain cancer growth. Here, we showed that CLU (clusterin) is localized to mitochondria to induce mitophagy controlling mitochondrial damage in oral cancer cells. Moreover

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