SML2094
BIBO 3304 trifluoroacetate salt
≥98% (HPLC)
别名:
BIBO3304, N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-a-phenyl-benzeneacetamide trifluoroacetate
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所有图片(1)
About This Item
经验公式（希尔记法）:
C29H35N7O3 · xC2HF3O2
CAS号:
分子量:
529.63 (free base basis)
UNSPSC代码:
12352200
NACRES:
NA.77
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方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
运输
wet ice
储存温度
−20°C
SMILES字符串
N([C@H](CCCNC(=N)N)C(=O)NCc3ccc(cc3)CNC(=O)N)C(=O)C(c2ccccc2)c1ccccc1
InChI
1S/C29H35N7O3/c30-28(31)33-17-7-12-24(26(37)34-18-20-13-15-21(16-14-20)19-35-29(32)39)36-27(38)25(22-8-3-1-4-9-22)23-10-5-2-6-11-23/h1-6,8-11,13-16,24-25H,7,12,17-19H2,(H,34,37)(H,36,38)(H4,30,31,33)(H3,32,35,39)/t24-/m1/s1
InChI key
TVMJSGGZULFVCZ-XMMPIXPASA-N
生化/生理作用
BIBO 3304 is a highly potent and selective NPY Y1 receptor antagonist that inhibits food intake induces by NPY (neuropeptide Y) or fasting in rodents. BIBO3304 eliminates NPY effects on fear extinction retrieval in rats.
Highly potent and selective NPY Y1 receptor antagonist
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Lauren L Vollmer et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(4), 1306-1315 (2016-01-29)
Neuropeptide Y (NPY), a 36 aa peptide, regulates stress and emotional behaviors. Preclinical and clinical studies support an association of NPY with trauma-evoked syndromes such as posttraumatic stress disorder (PTSD), although the exact contribution of NPY is not clear. In
H A Wieland et al.
British journal of pharmacology, 125(3), 549-555 (1998-11-07)
1. The novel Y1-selective argininamide derivative BIBO 3304 ((R)-N-[[4-(aminocarbonylaminomethyl)-phenyl]methyl]-N2-(diphen ylacetyl)-argininamide trifluoroacetate) has been synthesized and was examined for its subtype selectivity, its in vitro antagonistic properties and its food intake inhibitory properties. 2. BIBO 3304 displayed subnanomolar affinity for both
Shlomi Cohen et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(3), 774-790 (2014-09-23)
The hypothalamic-pituitary-adrenal (HPA) axis displays a characteristic circadian pattern of corticosterone release, with higher levels at the onset of the active phase and lower levels at the onset of the inactive phase. As corticosterone levels modify the response to stress
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