所有图片(1)
别名:
2-[5-(4-chlorophenyl)-2-furanyl]-2,5-dihydro-4-hydroxy-1-(6-methyl-2-benzothiazolyl)-5-oxo-1H-pyrrole-3-carboxylic acid ethyl ester
经验公式（希尔记法）:
C25H19ClN2O5S
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检测方案
≥98% (HPLC)
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
运输
ambient
储存温度
2-8°C
SMILES字符串
O=C1C(O)=C(C(OCC)=O)C(C2=CC=C(C3=CC=C(Cl)C=C3)O2)N1C4=NC(C=CC(C)=C5)=C5S4
生化/生理作用
PS432 is an allosteric inhibitor of Protein Kinase C (PKC) that targets regulatory site (PIF-pocket) present in the kinase domain. PS432 potently inhibits non-small cell lung cancer cells proliferation and tumor growth without side effects in a mouse xenograft model.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Jose M Arencibia et al.
ACS chemical biology, 12(2), 564-573 (2017-01-04)
There is a current and pressing need for improved cancer therapies. The use of small molecule kinase inhibitors and their application in combinatorial regimens represent an approach to personalized targeted cancer therapy. A number of AGC kinases, including atypical Protein
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