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Merck
CN

SML1971

Sigma-Aldrich

LLY-284

≥98% (HPLC)

别名:

(2R,3R,4S,5R)-2-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((S)-hydroxy(phenyl)methyl)tetrahydrofuran-3,4-diol, (S)-5′-phenyl-7-deazaadenosine; 6-amino-9-[(S)-5′-phenyl(ribofuranosyl)]-7-deazapurine, LLY 284, LLY284

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About This Item

经验公式(希尔记法):
C17H18N4O4
分子量:
342.35
UNSPSC代码:
12352200
NACRES:
NA.77

检测方案

≥98% (HPLC)

形式

powder

颜色

white to beige

储存温度

2-8°C

SMILES字符串

O[C@@H]1[C@@H]([C@@H](O)C2=CC=CC=C2)O[C@@H](N3C(N=CN=C4N)=C4C=C3)[C@@H]1O

生化/生理作用

LLY-284 is the less potent diastereomer of the potent SAM-competitive PRMT5 inhibitor LLY-283 (IC50 = 20 nM against PRMT5-catalyzed methylation of an H4R3-derived peptide substrate) and an ideal control compound for cellular studies. For characterization details of the active probe, LLY-283, please visit the LLY-283 probe summary on the Structural Genomics Consortium (SGC) website.

LLY-283, the active probe, is available from Sigma. To learn more about and purchase LLY-283, click here.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

特点和优势

LLY-284 is a negative control for LLY-283, an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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