所有图片(1)
别名:
2-Chloro-4-[5-[[2-[(ethylamino)thioxomethyl]hydrazinylidene]methyl]-2-furanyl]-benzoic acid
经验公式（希尔记法）:
C15H14ClN3O3S
推荐产品
检测方案
≥98% (HPLC)
形式
powder
颜色
white to brown
溶解性
DMSO: 15 mg/mL, clear
储存温度
2-8°C
SMILES字符串
O=C(C(C=CC(C1=CC=C(C=NNC(NCC)=S)O1)=C2)=C2Cl)O
生化/生理作用
PKUMDL-WQ-2201 is a potent and selective non-NAD+-competing allosteric inhibitor of phosphoglycerate dehydrogenase (PHGDH) that selectively inhibits serine synthesis in cancer cells. PKUMDL-WQ-2201 binds to allosteric site II, which is located in the substrate-binding domain. PKUMDL-WQ-2201 inhibits tumor growth of MDA-MB-468 xenografts in mice.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Qian Wang et al.
Cell chemical biology, 24(1), 55-65 (2017-01-04)
Metabolic reprogramming in cancer cells facilitates growth and proliferation. Increased activity of the serine biosynthetic pathway through the enzyme phosphoglycerate dehydrogenase (PHGDH) contributes to tumorigenesis. With a small substrate and a weak binding cofactor, (NAD+), inhibitor development for PHGDH remains
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