生化/生理作用
GA3-AM是植物激素赤霉素的细胞可渗透类似物，可充当化学二聚剂或二聚体化学诱导剂。Ga3和雷帕霉素化学诱导的二聚系统是正交的。GA3-AM已与雷帕霉素二聚化系统和CRISPR/Cas9激活剂一起用于时间上控制CRISPR/Cas9激活剂的功能，从而实现了多个基因的时间调控。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Takafumi Miyamoto et al.
Nature chemical biology, 8(5), 465-470 (2012-03-27)
Using a newly synthesized gibberellin analog containing an acetoxymethyl group (GA(3)-AM) and its binding proteins, we developed an efficient chemically inducible dimerization (CID) system that is completely orthogonal to existing rapamycin-mediated protein dimerization. Combining the two systems should allow applications
Zehua Bao et al.
ACS synthetic biology, 6(4), 686-693 (2017-01-06)
The concerted action of multiple genes in a time-dependent manner controls complex cellular phenotypes, yet the temporal regulation of gene expressions is restricted on a single-gene level, which limits our ability to control higher-order gene networks and understand the consequences
Shameika R Wilmington et al.
PloS one, 11(4), e0152679-e0152679 (2016-04-05)
A common way to study protein function is to deplete the protein of interest from cells and observe the response. Traditional methods involve disrupting gene expression but these techniques are only effective against newly synthesized proteins and leave previously existing
Maxime Boutry et al.
Nature communications, 12(1), 5354-5354 (2021-09-11)
Mitochondrial division is not an autonomous event but involves multiple organelles, including the endoplasmic reticulum (ER) and lysosomes. Whereas the ER drives the constriction of mitochondrial membranes, the role of lysosomes in mitochondrial division is not known. Here, using super-resolution
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