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SML1954

X-34

Name: X-34
Brand: SIGMA

≥90% (HPLC), powder, amyloid-specific fluorescent dye

别名:

1,4-双(3-羧基-4-羟基苯基乙烯基)苯

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关于此项目

经验公式（希尔记法）:

C₂₄H₁₈O₆

化学文摘社编号:

215294-98-7

分子量:

402.40

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD30474509

Assay:

≥90% (HPLC)

Form:

powder

Quality level:

100

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属性

产品名称

X-34, ≥90% (HPLC)

Quality Level

100

assay

≥90% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2.0 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC(C=C1)=C(C(O)=O)C=C1C=CC2=CC=C(C=CC3=CC=C(O)C(C(O)=O)=C3)C=C2

InChI

1S/C24H18O6/c25-21-11-9-17(13-19(21)23(27)28)7-5-15-1-2-16(4-3-15)6-8-18-10-12-22(26)20(14-18)24(29)30/h1-14,25-26H,(H,27,28)(H,29,30)

InChI key

MCBNOAYTZBUCSX-UHFFFAOYSA-N

说明

Biochem/physiol Actions

X-34（1,4-双（3-羧基-4-羟基苯基乙烯基）-苯）是参与到降低Aβ42水平（淀粉样-β肽的42个残基异构体）的一种小分子γ-分泌酶调节因子（GSM）。X-34还被用于在活的转基因秀丽隐杆线虫体内对具有经典淀粉样纤维超微结构的细胞内免疫反应性沉积物进行可视化。它还可作为组织化学染色剂用于确定阿尔茨海默氏′病（AD）的病理变化。

X-34是一种荧光淀粉样特异性染料。它与Pittsburgh CompoundB的结合位点不同，并且是β-折叠结构的一种高度荧光标记。

荧光淀粉样特异性染料

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000499646

0000453790

0000426175

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Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34

Link CD

Neurobiology of Aging, 22, 217-226 (2001)

Beneficial Effects of Cyclic Ether 2-Butoxytetrahydrofuran from Sea Cucumber Holothuria scabra against Aβ Aggregate Toxicity in Transgenic Caenorhabditis elegans and Potential Chemical Interaction.

Taweesak Tangrodchanapong et al.

Molecules (Basel, Switzerland), 26(8) (2021-05-01)

The pathological finding of amyloid-β (Aβ) aggregates is thought to be a leading cause of untreated Alzheimer's disease (AD). In this study, we isolated 2-butoxytetrahydrofuran (2-BTHF), a small cyclic ether, from Holothuria scabra and demonstrated its therapeutic potential against AD

INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia.

Andy P Tsai et al.

Neurobiology of disease, 153, 105303-105303 (2021-02-26)

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, robust microgliosis, neuroinflammation, and neuronal loss. Genome-wide association studies recently highlighted a prominent role for microglia in late-onset AD (LOAD). Specifically, inositol polyphosphate-5-phosphatase (INPP5D), also known as SHIP1

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全球贸易项目编号

货号	GTIN
SML1954-5MG	04061832983868
SML1954-25MG	04061832983851