所有图片(1)
别名:
7-Chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthalenylmethyl)-2H-1,4-benzodiazepin-2-one
经验公式（希尔记法）:
C27H21ClN2O2
推荐产品
质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
ClC1=CC=C2C(C(C3=CC=C(O)C=C3)=NC(CC4=CC=C(C=CC=C5)C5=C4)C(N2C)=O)=C1
InChI
1S/C27H21ClN2O2/c1-30-25-13-10-21(28)16-23(25)26(19-8-11-22(31)12-9-19)29-24(27(30)32)15-17-6-7-18-4-2-3-5-20(18)14-17/h2-14,16,24,29H,15H2,1H3
InChI key
IJEUIRDNQUQMFU-UHFFFAOYSA-N
应用
Bz-423 has been used as a mitochondrial inner membrane pore (MIMP) reagent to study its effect on oxygen consumption rate (OCR) and ATP synthesis in HepG2 cells.
生化/生理作用
Bz-423 is an inhibitor of mitochondrial F1F0 ATP synthase. It binds the oligomycin sensitivity conferring protein (OSCP) component of mitochondrial F1F0-ATPase, resulting in superoxide generation and apoptosis. BZ-423 was shown to block multidrug-resistant melanoma cells. In another study, Bz-423 selectively increased superoxide and induced the apoptosis of alloreactive T cells, which arrested established Graft versus Host Disease.
Bz-423 stimulates mitochondrial inner membrane pore (MIMP) opening in isolated mitochondria.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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