质量水平
检测方案
≥98% (HPLC)
形式
powder
储存条件
desiccated
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
O=C(OCC)C1CSC(CC2=CC=C(OCC3=CC=C([N+]([O-])=O)C=C3)C=C2)N1
InChI
1S/C20H22N2O5S/c1-2-26-20(23)18-13-28-19(21-18)11-14-5-9-17(10-6-14)27-12-15-3-7-16(8-4-15)22(24)25/h3-10,18-19,21H,2,11-13H2,1H3
InChI key
ZVYIJXLMBWCGHP-UHFFFAOYSA-N
应用
SN-6已作为Na+/Ca++交换蛋白(NCX)的选择性抑制剂，用于研究其对小鼠轴突损伤的神经保护作用。
生化/生理作用
SN-6参与肾小管细胞中的抗缺氧和复氧诱导细胞损伤保护。
SN-6是Na+/Ca++交换体（NCX）的选择性抑制剂，对NCX1亚型具有一定的选择性。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Satomi Kita et al.
Annals of the New York Academy of Sciences, 1099, 529-533 (2007-04-21)
We investigated the pharmacological properties of SN-6, a new selective Na+/Ca2+ exchanger (NCX) inhibitor. SN-6 preferentially inhibited the (45)Ca2+ uptake via NCX compared with the (45)Ca2+ efflux via NCX in NCX-transfected fibroblasts. SN-6 was three- to fivefold more inhibitory to
Anton Omelchenko et al.
Cell death & disease, 10(10), 727-727 (2019-09-29)
Mild traumatic brain injury (mTBI) is a frequently overlooked public health concern that is difficult to diagnose and treat. Diffuse axonal injury (DAI) is a common mTBI neuropathology in which axonal shearing and stretching induces breakdown of the cytoskeleton, impaired
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