推荐产品
表单
powder
质量水平
储存条件
protect from light
颜色
light yellow to dark yellow
溶解性
DMSO: 10 mg/mL, clear
储存温度
−20°C
SMILES字符串
CN(CC(O)=O)C1=S=[Mn-4]([C+]=O)([C+]=O)([C+]=O)([C+]=O)S1
生化/生理作用
CORM-401（Mn(CO)4(S2CNMe(CH2CO2H))）是一种可生成至少三摩尔当量CO的含锰一氧化碳释放分子（CORM）。由于CO的可逆性结合，CORM-401在溶液中相对稳定（在PBS中放置4小时后CO的损失为0.33 mol当量；时间零点的[CORM-401] =1 mM），而当存在CO受体或能组织CO重新集合的配体存在时会导致更多的CO释放（在44 μM的肌红蛋白存在下，在0.8分钟的t1/2时3.2 mol当量的CO被转移到了铁上；时间零点的[CORM-401] = 10 μM）。据报道，通过CORM-401实现的CO输入可解偶联线粒体呼吸且抑制人内皮细胞中的糖酵解（10-100 μM），并松弛与去氧肾上腺素预收缩的离体大鼠主动脉环（25 μM）。
可比CORM-A1和CORM-3生成三倍更多CO的含锰一氧化碳释放分子（CORM）。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Sarah Fayad-Kobeissi et al.
Biochemical pharmacology, 102, 64-77 (2016-01-02)
Carbon monoxide (CO) is generated by heme oxygenase-1 (HO-1) and displays important signaling, anti-apoptotic and anti-inflammatory activities, indicating that pharmacological agents mimicking its action may have therapeutic benefit. This study examined the biochemical and pharmacological properties of CORM-401, a recently
Sian H Crook et al.
Dalton transactions (Cambridge, England : 2003), 40(16), 4230-4235 (2011-03-16)
[Mn(CO)(4){S(2)CNMe(CH(2)CO(2)H)}], 1, is shown to be a CO releasing molecule providing at least three moles CO per mole of compound. The mechanism of CO loss is dissociative and reversible and was investigated using Gaussian 09 calculations. The reversible binding of
Patrycja Kaczara et al.
Biochimica et biophysica acta, 1847(10), 1297-1309 (2015-07-18)
Carbon monoxide (CO), a product of heme degradation by heme oxygenases, plays an important role in vascular homeostasis. Recent evidence indicates that mitochondria are among a number of molecular targets that mediate the cellular actions of CO. In the present
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