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安全信息

SML1929

Sigma-Aldrich

Equisetin

(Fusarium equiseti), ≥97% (HPLC)

别名:

(3E,5S)-3-[[(1S,2R,4aS,6R,8aR)-1,6-dimethyl-2-[(E)-prop-1-enyl]-4a,5,6,7,8,8a-hexahydro-2H-naphthalen-1-yl]-hydroxymethylidene]-5-(hydroxymethyl)-1-methylpyrrolidine-2,4-dione

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About This Item

经验公式（希尔记法）:
C22H31NO4
CAS号:
57749-43-6
分子量:
373.49
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

200

生物来源

(Fusarium equiseti)

方案

≥97% (HPLC)

表单

powder

溶解性

DMSO: soluble 1 mg/mL
chloroform: soluble 5 mg/mL

运输

ambient

储存温度

−20°C

SMILES字符串

C[C@H]1C[C@]2([H])[C@@]([C@](C)(/C(O)=C3C([C@H](CO)N(C)C/3=O)=O)[C@H](/C=C/C)C=C2)([H])CC1

InChI

1S/C22H31NO4/c1-5-6-15-9-8-14-11-13(2)7-10-16(14)22(15,3)20(26)18-19(25)17(12-24)23(4)21(18)27/h5-6,8-9,13-17,24,27H,7,10-12H2,1-4H3/b6-5+/t13-,14-,15-,16-,17+,22-/m1/s1

InChI key

SLOQQJFOWFUUMP-KNQICWOTSA-N

生化/生理作用

Equisetin is a tetramic acid analog derived from Fusarium equisti. Equisetin is mainly known for its antibiotic and cytotoxic activity and for its inhibitory effect on HIV-1 integrase. Inhibition of HIV integrase by Equisetin was reported with IC50 values of 5-20 μM. Moreover, it was shown that Equisetin specifically inhibits the substrate anion carriers of the inner membrane of mitochondria and acts nonspecifically on protein membranes and protein hydrophobic domains. In addition, it was demonstrated that Equisetin causes phytotoxicity by causing root Necrosis and was also identified in a mycotoxin cocktail associated with cattle feeding problems.
Equisetin is a tetramic acid analog derived from Fusarium equisti.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
12170506
067M4154V
12170505
089M4117V

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D Hazuda et al.
Antiviral chemistry & chemotherapy, 10(2), 63-70 (1999-05-21)
We have identified a series of novel inhibitors of human immunodeficiency virus type 1 (HIV-1) integrase by randomly screening natural product extracts using an in vitro biochemical assay designed to identify inhibitors of integrase-catalysed strand transfer. Equisetin recovered from the
T König et al.
Journal of bioenergetics and biomembranes, 25(5), 537-545 (1993-10-01)
The effect of equisetin, an antibiotic produced by Fusarium equiseti, has been studied on mitochondrial functions (respiration, ATPase, ion transport). Equisetin inhibits the DNP-stimulated ATPase activity of rat liver mitochondria and mitoplasts in a concentration-dependent manner; 50% inhibition is caused
Agha W Yunus et al.
Toxins, 7(6), 2188-2197 (2015-06-16)
Cottonseed cake in South East Asia has been associated with health issues in ruminants in the recent years. The present study was carried out to investigate the health issues associated with cottonseed cake feeding in dairy animals in Pakistan. All

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