推荐产品
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
H2O: 10 mg/mL, clear
储存温度
2-8°C
SMILES字符串
[S](=O)(=O)(C)c1nc(c(cn1)Cl)C(=O)O
InChI
1S/C6H5ClN2O4S/c1-14(12,13)6-8-2-3(7)4(9-6)5(10)11/h2H,1H3,(H,10,11)
InChI key
WZUPWJVRWIVWEF-UHFFFAOYSA-N
生化/生理作用
PK11007 is a thiol-reactive anticancer agent that stabilizes wild type and mutant p53 through selective alkylation of two surface cysteines without interfering with its DNA binding.
PK11007 is a thiol-reactive anticancer agent that stabilizes wild type and mutant p53 through selective alkylation of two surface cysteines without interfering with its DNA binding. Additionally independently from p53, PK11007 impairs reactive oxygen species (ROS) detoxification in a number of mutant p53 cancer cells. PK11007 exhibits anticancer activity in number of cancer cell lines while shoving low cytotoxicity toward normal cells.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells.
Matthias R Bauer et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(36), E5271-E5280 (2016-08-24)
The tumor suppressor p53 has the most frequently mutated gene in human cancers. Many of p53's oncogenic mutants are just destabilized and rapidly aggregate, and are targets for stabilization by drugs. We found certain 2-sulfonylpyrimidines, including one named PK11007, to
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