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SML1890

Sigma-Aldrich

MK204

≥98% (HPLC)

别名:

2-[5-Chloro-2-[[[(2,3,4,5,6-pentabromophenyl)methyl]amino]carbonyl]phenoxy]-acetic acid

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About This Item

经验公式（希尔记法）:
C16H9Br5ClNO4
CAS号:
1959605-73-2
分子量:
714.22
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 3 mg/mL, clear (warmed)

储存温度

2-8°C

SMILES字符串

O=C(C1=C(OCC(O)=O)C=C(C=C1)Cl)NCC(C(Br)=C(C(Br)=C2Br)Br)=C2Br

InChI

1S/C16H9Br5ClNO4/c17-11-8(12(18)14(20)15(21)13(11)19)4-23-16(26)7-2-1-6(22)3-9(7)27-5-10(24)25/h1-3H,4-5H2,(H,23,26)(H,24,25)

InChI key

QYSFXUVFRUYJCZ-UHFFFAOYSA-N

生化/生理作用

MK204 is a potent and selective inhibitor of aldo-keto reductase family member 1B10 (AKR1B10).
MK204 is a potent and selective inhibitor of aldo-keto reductase family member 1B10 (AKR1B10). AKR1B10 is induced in several cancer types, in particular, hepatocellular carcinoma, and may be involved with drug resistance. MK204 appears to target a distinct AKR1B10 inner specificity pocket not present in the closely related aldose reductase. MK204 had an IC50 value of 80 nM compared to an IC50 value of 21.7 μM for aldose reductase.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000011954
0000011953
047M4746V

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Alexandra Cousido-Siah et al.
ACS chemical biology, 11(10), 2693-2705 (2016-10-22)
Human enzyme aldo-keto reductase family member 1B10 (AKR1B10) has evolved as a tumor marker and promising antineoplastic target. It shares high structural similarity with the diabetes target enzyme aldose reductase (AR). Starting from the potent AR inhibitor IDD388, we have

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