SML1877
他达拉非
≥98% (HPLC), PDE5 inhibitor, powder
别名:
(6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione, ICI-351
产品名称
他达拉非, ≥98% (HPLC)
SMILES string
N21[C@H](Cc3c4c([nH]c3[C@H]2c5cc6c(cc5)OCO6)cccc4)C(=O)N(CC1=O)C
InChI
1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1
InChI key
WOXKDUGGOYFFRN-IIBYNOLFSA-N
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D +68 to +78°, c = 1 in chloroform-d
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
−20°C
Quality Level
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Biochem/physiol Actions
Tadalafil is a potent, selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) used to treat erectile dysfunction, pulmonary hypertension, and benign prostatic hyperplasia (BPH).
This β-carboline-based drug has a long elimination half-life of about 18 hours.
This β-carboline-based drug has a long elimination half-life of about 18 hours.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Kazuhiko Fukumoto et al.
International journal of urology : official journal of the Japanese Urological Association, 24(3), 206-210 (2016-12-30)
To investigate the effects of tadalafil on vascular endothelial function and cardiovascular risk in patients with prostatic hyperplasia. Tadalafil 5 mg was given to 20 patients with prostatic hyperplasia for whom an α1-blocker was ineffective. Voiding symptoms and vascular endothelial
Alaa E El-Sisi et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 84, 861-869 (2016-10-14)
Life threatening conditions characterized by renal ischemia/reperfusion (RIR) such as kidney transplantation, partial nephrectomy, renal artery angioplasty, cardiopulmonary bypass and aortic bypass surgery, continue to be among the most frequent causes of acute renal failure. The current study investigated the
Hossein Karami et al.
Urology journal, 13(6), 2920-2926 (2016-12-09)
To compare monotherapy with tadalafil or tamsulosin and their combination therapy in men with benignprostatic hyperplasia and erectile dysfunction by comparing IPSS score, prostate volume and Qmax and someother outcomes. This randomized, single-blind, paralleled group clinical trial was done in
A once-daily dose of tadalafil for erectile dysfunction: compliance and efficacy.
Washington III S L and Shindel A W
Drug design, development and therapy, 4, 159-159 (2010)
Luqiang Wang et al.
American journal of physiology. Endocrinology and metabolism, 315(4), E446-E453 (2018-06-20)
Cyclic GMP (cGMP) is an important intracellular regulator of endochondral bone growth and skeletal remodeling. Tadalafil, an inhibitor of the phosphodiesterase (PDE) type 5 (PDE5) that specifically hydrolyzes cGMP, is increasingly used to treat children with pulmonary arterial hypertension (PAH)
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