质量水平
检测方案
≥98% (HPLC)
形式
powder
旋光性
[α]/D +68 to +78°, c = 1 in chloroform-d
颜色
white to beige
溶解性
DMSO: 20 mg/mL, clear
储存温度
−20°C
InChI
1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1
InChI key
WOXKDUGGOYFFRN-IIBYNOLFSA-N
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生化/生理作用
Tadalafil is a potent, selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) used to treat erectile dysfunction, pulmonary hypertension, and benign prostatic hyperplasia (BPH).
This β-carboline-based drug has a long elimination half-life of about 18 hours.
This β-carboline-based drug has a long elimination half-life of about 18 hours.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Alaa E El-Sisi et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 84, 861-869 (2016-10-14)
Life threatening conditions characterized by renal ischemia/reperfusion (RIR) such as kidney transplantation, partial nephrectomy, renal artery angioplasty, cardiopulmonary bypass and aortic bypass surgery, continue to be among the most frequent causes of acute renal failure. The current study investigated the
Hossein Karami et al.
Urology journal, 13(6), 2920-2926 (2016-12-09)
To compare monotherapy with tadalafil or tamsulosin and their combination therapy in men with benignprostatic hyperplasia and erectile dysfunction by comparing IPSS score, prostate volume and Qmax and someother outcomes. This randomized, single-blind, paralleled group clinical trial was done in
Kazuhiko Fukumoto et al.
International journal of urology : official journal of the Japanese Urological Association, 24(3), 206-210 (2016-12-30)
To investigate the effects of tadalafil on vascular endothelial function and cardiovascular risk in patients with prostatic hyperplasia. Tadalafil 5 mg was given to 20 patients with prostatic hyperplasia for whom an α1-blocker was ineffective. Voiding symptoms and vascular endothelial
Luqiang Wang et al.
American journal of physiology. Endocrinology and metabolism, 315(4), E446-E453 (2018-06-20)
Cyclic GMP (cGMP) is an important intracellular regulator of endochondral bone growth and skeletal remodeling. Tadalafil, an inhibitor of the phosphodiesterase (PDE) type 5 (PDE5) that specifically hydrolyzes cGMP, is increasingly used to treat children with pulmonary arterial hypertension (PAH)
A once-daily dose of tadalafil for erectile dysfunction: compliance and efficacy.
Washington III S L and Shindel A W
Drug design, development and therapy, 4, 159-159 (2010)
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