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Merck
CN

SML1868

鸦胆子苦醇

From Brucia javanica, ≥95% (HPLC), NRF2 inhibitor, powder

别名:

(+)-鸦胆子苦醇, (11β,12α,15β)-13,20-环氧-3,11,12-三羟基-15-[（3-甲基-1-氧代-2-丁烯-1-基）氧]-2,16-二氧代-picras-3-烯-21-酸甲酯, NSC 172924, 鸦胆子苦醇

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关于此项目

经验公式（希尔记法）:
C26H32O11
化学文摘社编号:
14907-98-3
分子量:
520.53
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
MFCD23726642

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产品名称

鸦胆子苦醇, ≥95% (HPLC)

InChI

1S/C26H32O11/c1-10(2)6-15(28)37-18-20-25-9-35-26(20,23(33)34-5)21(31)17(30)19(25)24(4)8-13(27)16(29)11(3)12(24)7-14(25)36-22(18)32/h6,12,14,17-21,29-31H,7-9H2,1-5H3/t12-,14+,17+,18+,19+,20+,21-,24-,25+,26-/m0/s1

SMILES string

CC1=C(O)C(C[C@@]2(C)[C@@]1([H])C[C@]3([H])[C@]45[C@]2([H])[C@@H](O)[C@H](O)[C@](OC5)(C(OC)=O)[C@]4([H])[C@@H](OC(C=C(C)C)=O)C(O3)=O)=O

InChI key

ZZZYHIMVKOHVIH-VILODJCFSA-N

biological source

(Brucia javanica)

assay

≥95% (HPLC)

form

powder

optical activity

[α]/D +35 to +44°, c = 0.5 in acetone

storage condition

desiccated

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

−20°C

Quality Level

100

相关类别

Application

鸦胆子苦醇已被用于研究 Nrf2（核因子，红系 2 样 2）在肠缺血/再灌注诱导损伤中的保护作用。

Biochem/physiol Actions

鸦胆子苦醇促进 Nrf2（核因子，红系 2 样 2）泛素化和降解。鸦胆子苦醇上调多种核糖体成分的表达，控制大分子复合物功能。
鸦胆子苦醇是一种植物来源的天然苦木苦味素，在癌症培养物中表现出广泛的细胞毒性（IC 50 <1 μM， 457 个癌细胞系），通过抑制细胞蛋白的从头合成（在 A549 细胞中有效浓度 <50 nM），包括 NRF2
鸦胆子苦醇是一种植物来源的天然苦木苦味素，表现出广泛的细胞毒性。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000443692
0000443691
0000443691
0000443692
0000277797

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