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Merck
CN

SML1853

Sigma-Aldrich

Kaempferitrin

≥97% (NMR)

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别名:
3,7-Bis((6-deoxy-α-L-mannopyranosyl)oxy)-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, Kaempferol 3,7-dirhamnoside, Lespedin, Lespenefril, Lespenephryl
经验公式(希尔记法):
C27H30O14
CAS号:
分子量:
578.52
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77

生物来源

(Cinnamomum sp.)

质量水平

检测方案

≥97% (NMR)

形式

powder

储存条件

desiccated
protect from light

颜色

white to beige

储存温度

−20°C

SMILES字符串

OC(C=C1)=CC=C1C2=C(O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)C(C4=C(O)C=C(O[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)C=C4O2)=O

InChI

1S/C27H30O14/c1-9-17(30)20(33)22(35)26(37-9)39-13-7-14(29)16-15(8-13)40-24(11-3-5-12(28)6-4-11)25(19(16)32)41-27-23(36)21(34)18(31)10(2)38-27/h3-10,17-18,20-23,26-31,33-36H,1-2H3/t9-,10-,17-,18-,20+,21+,22+,23+,26-,27-/m0/s1

InChI key

PUPKKEQDLNREIM-QNSQPKOQSA-N

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相关类别

生化/生理作用

Kaempferitrin (Lespenefril) is a naturally-occurring kaempferol glycoside with antimicrobial, antioxidant, and anti-inflammatory activities.
Kaempferitrin is a flavonol glycoside, present in several plants, predominant in Bauhinia. It is known to stimulate insulin signaling pathway and induces glucose uptake, by mediating GLUT4 (glucose transporter 4) translocation to adipocyte membrane.. Kaempferitrin aids in lowering blood glucose level and therefore helps to improve the glycemic condition in diabetic animals.

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Kaempferitrin activates the insulin signaling pathway and stimulates secretion of adiponectin in 3T3-L1 adipocytes
Tzeng YM, et al.
European Journal of Pharmacology, 607(1-3), 27-34 (2009)
Medicinal and Aromatic Plants of South America: Brazil, 142-142 (2018)
Xue-Qin Ma et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 22(13), 1159-1162 (2015-11-26)
Podocarpium podocarpum (DC.), an edible and medicinal plant popularly used for the treatment of bruises and fracture in Chinese folk medicine, has been proved to possess significant antiosteoporotic effect in our latest research. Our study aimed to investigate the in
Julia Cassani et al.
Molecules (Basel, Switzerland), 19(12), 21442-21461 (2014-12-24)
We evaluated the antidepressant-like effect of kaempferitrin (Km) isolated from the plant Justicia spicigera (Asteraceae), which is used in traditional medicine for relieving emotional disorders, such as "la tristeza" (sadness or dysthymia) and "el humor" (mood changes). The actions of
Discovery and Development of Antidiabetic Agents from Natural Products, 118-118 (2016)

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