SML1845
Thapsigargin Ready Made Solution
≥98% (HPLC), 10 mM in DMSO
别名:
CHEBI:9516, CHEMBL96926, MFCD00083511, UNII-Z96BQ26RZD, Z96BQ26RZD, [(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetyloxy-4-butanoyloxy-3,3a-dihydroxy-3,6,9-trimethyl-8-[(Z)-2-methylbut-2-enoyl]oxy-2-oxo-4,5,6a,7,8,9b-hexahydroazuleno[4,5-b]furan-7-yl] octanoate
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所有图片(1)
About This Item
生物来源
(Thapsia garganica L seeds)
质量水平
检测方案
≥98% (HPLC)
形式
DMSO solution
浓度
10 mM in DMSO
运输
dry ice
储存温度
−20°C
InChI
1S/C34H50O12/c1-9-12-13-14-15-17-24(37)43-28-26-25(20(5)27(28)44-30(38)19(4)11-3)29-34(41,33(8,40)31(39)45-29)22(42-23(36)16-10-2)18-32(26,7)46-21(6)35/h11,22,26-29,40-41H,9-10,12-18H2,1-8H3/b19-11-/t22-,26+,27-,28-,29-,32-,33+,34+/m0/s1
InChI key
IXFPJGBNCFXKPI-FSIHEZPISA-N
应用
毒胡萝卜素即配型溶液可作为体内生长和体外翻译检测的阴性对照。
生化/生理作用
毒胡萝卜素是一种有效的钙离子泵抑制剂，位于骨骼肌、心肌、肌肉和脑组织的肌质网（SR）和内质网（ER）微粒体上。钙离子泵的抑制会导致细胞内钙离子水平上升。100nM浓度的毒胡萝卜素可有效抑制心肌和骨骼肌中的SR Ca2+ -三磷酸腺苷酶（ATP酶）。毒胡萝卜素还可通过干扰自噬体-溶酶体融合而有效阻断自噬。
毒胡萝卜素是一种有效的钙离子泵抑制剂，位于骨骼肌、心肌、肌肉和脑组织的肌质网（SR）和内质网（ER）微粒体上。
其他说明
在浓度为10 mM的DMSO中提供了毒胡萝卜素即用型溶液。该溶液可用 DMSO 进一步稀释至 2 mM 浓度。建议将预先制好的毒胡萝卜素溶液小等份保存于-20°C下。
WGK
WGK 2
闪点(°F)
closed cup
闪点(°C)
closed cup
Partial inactivation of cardiac 14-3-3 protein in vivo elicits endoplasmic reticulum stress (ERS) and activates ERS-initiated apoptosis in ERS-induced mice
<BIG>Sari FR, et al.</BIG>
Cellular Physiology and Biochemistry, 167-178 (2010)
M Alsaqati et al.
British journal of pharmacology, 171(3), 701-713 (2013-10-22)
The P2Y₁₄ receptor is the newest member of the P2Y receptor family; it is G(i/o) protein-coupled and is activated by UDP and selectively by UDP-glucose and MRS2690 (2-thiouridine-5'-diphosphoglucose) (7-10-fold more potent than UDP-glucose). This study investigated whether P2Y₁₄ receptors were
J Lytton et al.
The Journal of biological chemistry, 266(26), 17067-17071 (1991-09-15)
The role of ATP-dependent calcium uptake into intracellular storage compartments is an essential feature of hormonally induced calcium signaling. Thapsigargin, a non-phorboid tumor promoter, increasingly is being used to manipulate calcium stores because it induces a hormone-like elevation of cytosolic
Thapsigargin blocks the induction of long-term potentiation in rat hippocampal slices
<BIG>Harvey J and Collingridge GL</BIG>
Neuroscience Letters, 197-200 (1992)
Zhouteng Tao et al.
Human molecular genetics, 24(9), 2426-2441 (2015-01-13)
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are the two common neurodegenerative diseases that have been associated with the GGGGCC·GGCCCC repeat RNA expansion in a noncoding region of C9orf72. It has been previously reported that unconventional repeat-associated non-ATG (RAN)
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