推荐产品
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
yellow to orange
溶解性
DMSO: 15 mg/mL, clear
储存温度
2-8°C
SMILES字符串
NC1=CC=C(/C=C2SC(NC\2=O)=N)C=C1
InChI
1S/C10H9N3OS/c11-7-3-1-6(2-4-7)5-8-9(14)13-10(12)15-8/h1-5H,11H2,(H2,12,13,14)/b8-5-
InChI key
QXOIZYPBCJHYLN-YVMONPNESA-N
生化/生理作用
PFM39 是有效的、细胞可透过性 Mirin 类似物，可选择性抑制 MRE11 核酸外切酶活性，但不抑制核酸内切酶活性。
PFM39 是有效的、细胞可透过性 Mirin 类似物，可选择性抑制 MRE11 核酸外切酶活性，但不抑制核酸内切酶活性。 PFM39 以与 Mirin 相似的方式靶向 MRE11，但与 PFM01 不同，它可以阻断 dsDNA 磷酸骨架的旋转并选择性抑制 MRE11 核酸外切酶活性，但不能抑制核酸内切酶活性。在电离辐射（IR）后，FM39 可能会损害 1BR3-hTERT 成纤维细胞的 G2 相双链断裂（DSB）修复。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Lea Völkening et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(2), 2812-2820 (2020-01-08)
The Mre11A/RAD50/NBN complex (MRN) is an essential regulator of the cellular damage response after DNA double-strand breaks (DSBs). More recent work has indicated that MRN may also impact on the duration of mitosis. We show here that RAD50-deficient fibroblasts exhibit
Ronan Broderick et al.
Nature cell biology, 18(3), 271-280 (2016-01-26)
Repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) is critical for survival and genome stability of individual cells and organisms, but also contributes to the genetic diversity of species. A vital step in HR is MRN-CtIP-dependent end resection
Atsushi Shibata et al.
Molecular cell, 53(1), 7-18 (2013-12-10)
MRE11 within the MRE11-RAD50-NBS1 (MRN) complex acts in DNA double-strand break repair (DSBR), detection, and signaling; yet, how its endo- and exonuclease activities regulate DSBR by nonhomologous end-joining (NHEJ) versus homologous recombination (HR) remains enigmatic. Here, we employed structure-based design
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门