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产品名称
ML385, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 10 mg/mL, clear
储存温度
2-8°C
SMILES字符串
O=C(NC1=NC(C2=CC=C(N(C(C3=C(C)C=CC=C3)=O)CC4)C4=C2)=C(C)S1)CC5=CC(OCO6)=C6C=C5
InChI
1S/C29H25N3O4S/c1-17-5-3-4-6-22(17)28(34)32-12-11-20-15-21(8-9-23(20)32)27-18(2)37-29(31-27)30-26(33)14-19-7-10-24-25(13-19)36-16-35-24/h3-10,13,15H,11-12,14,16H2,1-2H3,(H,30,31,33)
InChI key
LINHYWKZVCNAMQ-UHFFFAOYSA-N
生化/生理作用
ML385 通过与 Neh1 结合来抑制 Nrf2 转录因子的活性，Neh1 是一个 CNC-bZIP 结构域，其能够使 Nrf2 与小 Maf 蛋白异二聚化，从而阻断 NRF2 转录活性。人们已对激活 Nrf2 进行了大量研究，因为它诱导细胞保护抗氧化基因的表达。然而，一些癌细胞可能以类似的方式利用 Nrf2 来使其存活。Nrf2 在某些癌症（例如非小细胞肺癌（NSCLC））中过表达，这通常是由于 KEAP1 功能缺失突变引起的，KEAP1 靶向 Nrf2 导致其发生蛋白酶体降解。研究发现 ML385 对带有 KEAP1 突变的 NSCLC 细胞具有特异性和选择性的抗肿瘤活性。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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分析证书(COA)
Lot/Batch Number
Amy M Ehrlich et al.
BMC microbiology, 20(1), 357-357 (2020-11-24)
Bifidobacterium longum subsp. infantis (B. infantis) is a commensal bacterium that colonizes the gastrointestinal tract of breast-fed infants. B. infantis can efficiently utilize the abundant supply of oligosaccharides found in human milk (HMO) to help establish residence. We hypothesized that
Yuanyuan Bian et al.
Molecular medicine reports, 25(1) (2021-11-10)
Vitiligo is a depigmentation disease commonly seen in clinical practice, mainly involving loss of functional epidermal pigment cells and hair follicle melanocytes. Narrow‑band ultraviolet B (NB‑UVB) has emerged as the first choice of treatment for vitiligo, but long‑term exposure may have
Yi Zhou et al.
Experimental and therapeutic medicine, 22(6), 1380-1380 (2021-10-16)
Hepatic ischemia-reperfusion injury (HIRI) is caused by blood flow recovery following ischemia. Baicalein (BAI), a natural antioxidant used in traditional Chinese medicine, eliminates excessive free radicals and protects the structure of the cell membrane. However, its protective mechanism against HIRI
Yanlian Xiong et al.
Stem cell research & therapy, 11(1), 468-468 (2020-11-06)
Mesenchymal stem cells (MSCs) were considered a regenerative therapeutic approach in both acute and chronic diseases. However, whether MSCs regulate the antioxidant metabolism of CD4+ T cells and weaken immunosenescence remains unclear. Here, we reported the protective effects of hPMSCs
Etay Ziv et al.
Radiology, 297(1), 225-234 (2020-08-12)
Background Intermediate stage hepatocellular carcinomas (HCCs) are treated by inducing ischemic cell death with transarterial embolization (TAE) or transarterial chemoembolization (TACE). A subset of HCCs harbor nuclear factor E2-related factor 2 (NRF2), a major regulator of the oxidative stress response
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