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Merck
CN

SML1818

Sigma-Aldrich

Pirodavir

≥98% (HPLC)

别名:

4-[2-[1-(6-Methyl-3-pyridazinyl)-4-piperidinyl]ethoxy]-benzoic acid ethyl ester, Ethyl 4-[2-[1-(6-methyl-3-pyridazinyl)-4-piperidinyl]ethoxy]benzoate, R 77975, R-77975, R77,975

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About This Item

经验公式(希尔记法):
C21H27N3O3
分子量:
369.46
MDL编号:
UNSPSC代码:
51111800
NACRES:
NA.77

质量水平

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear

储存温度

2-8°C

SMILES字符串

O=C(OCC)C1=CC=C(OCCC2CCN(C3=NN=C(C)C=C3)CC2)C=C1

InChI

1S/C21H27N3O3/c1-3-26-21(25)18-5-7-19(8-6-18)27-15-12-17-10-13-24(14-11-17)20-9-4-16(2)22-23-20/h4-9,17H,3,10-15H2,1-2H3

InChI key

KCHIOGFOPPOUJC-UHFFFAOYSA-N

生化/生理作用

Pirodavir is a broad-spectrum antipicornavirus agent that targets viral capsid protein VP1. Pirodavir is a broad spectrum inhibitor of human rhinovirus (HRV).

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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分析证书(COA)

Lot/Batch Number

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Céline Lacroix et al.
Virology journal, 12, 106-106 (2015-07-15)
Rhinovirus infections do not only cause common colds, but may also trigger severe exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Even though rhinoviruses have been the focus of extensive drug development efforts in the past, an anti-rhinoviral drug
Chris Mello et al.
Antimicrobial agents and chemotherapy, 58(3), 1546-1555 (2013-12-25)
Human rhinovirus type C (HRV-C) is a newly discovered enterovirus species frequently associated with exacerbation of asthma and other acute respiratory conditions. Until recently, HRV-C could not be propagated in vitro, hampering in-depth characterization of the virus replication cycle and
Donald F Smee et al.
Antiviral research, 131, 61-65 (2016-04-12)
Compounds were evaluated for antiviral activity in rhabdomyosarcoma (RD) cells against a recent 2014 clinical isolate of enterovirus D68 (EV-D68), a 1962 strain of EV-68D, rhinovirus 87 (RV-87, serologically the same as EV-D68), and enterovirus 71 (EV-71). Test substances included

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