SML1813
Ani9
别名:
(4-Chloro-2-methylphenoxy)-acetic acid [(2-methoxyphenyl)methylene]hydrazide, 2-(4-Chloro-2-methylphenoxy)-N-[(2-methoxyphenyl)methylideneamino]-acetamide, 2-(4-Chloro-2-methylphenoxy)-acetic acid 2-[(2-methoxyphenyl)methylene]hydrazide
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所有图片(1)
About This Item
经验公式（希尔记法）:
C17H17ClN2O3
CAS号:
分子量:
332.78
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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方案
≥98% (HPLC)
质量水平
表单
powder
颜色
white to beige
溶解性
DMSO: 25 mg/mL, clear
储存温度
2-8°C
SMILES字符串
CC1=C(OCC(NN=CC2=C(OC)C=CC=C2)=O)C=CC(Cl)=C1
InChI key
KDALDZRKOBJXIE-UHFFFAOYSA-N
应用
Ani9 has been used to find out the inappropriate modulation of the membrane protein functions that are involved in the 198 ADGRG2- or Gq-mediated regulation of fluid reabsorption in the efferent ductules.
生化/生理作用
2-(4-chloro-2-methylphenoxy)-N-[(2-methoxyphenyl)methylideneamino]-acetamide (Ani9), the most potent inhibitor, is the structural analog of Ani7. It may be considered as a novel candidate for drug therapy of cancer, hypertension, pain, diarrhea and asthma.
Ani9 is a potent and highly selective anoctamin1 (ANO1)/transmembrane protein 16A (TMEM16A) inhibitor that completely inhibited ANO1 chloride current with submicromolar potency. Ani9 does not affect the intracellular calcium signaling and CFTR chloride channel activity.
Ani9 is a potent and highly selective anoctamin1 (ANO1)/transmembrane protein 16A (TMEM16A) inhibitor.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Gq activity-and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility.
Zhang DL, et al.
eLife, 7, e33432-e33432 (2018)
Ani9, a novel potent small-molecule ANO1 inhibitor with negligible effect on ANO2.
Seo Y, et al.
PLoS ONE, 11(5), e0155771-e0155771 (2016)
Alexander Klimovich et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(30), 17854-17863 (2020-07-11)
Pacemaker neurons exert control over neuronal circuit function by their intrinsic ability to generate rhythmic bursts of action potential. Recent work has identified rhythmic gut contractions in human, mice, and hydra to be dependent on both neurons and the resident
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