推荐产品
产品名称
尿石素A, ≥97% (HPLC)
质量水平
方案
≥97% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 20 mg/mL, clear
储存温度
2-8°C
SMILES字符串
OC1=CC=C(C(C=CC(O)=C2)=C2C(O3)=O)C3=C1
InChI
1S/C13H8O4/c14-7-1-3-9-10-4-2-8(15)6-12(10)17-13(16)11(9)5-7/h1-6,14-15H
InChI key
RIUPLDUFZCXCHM-UHFFFAOYSA-N
应用
尿石素A已用于：
- 通过体外细胞增殖实验检测其对白血病细胞系的抗白血病作用
- 作为线粒体自噬激活剂，研究缺血再灌注(I/R)损伤时，磷酸甘油酸变位酶5(PGAM5)表达对线粒体自噬细胞死亡的影响
- 研究其经由P53-Mdm2-Snail通路对肺癌细胞上皮间质转化(EMT)的抑制作用
- 研究其激活沉默交配型信息调节因子2同源蛋白1(sirtuin 1/silent mating type information regulation 2 homolog 1, SIRT1)信号通路，对链脲菌素诱导的大鼠糖尿病性心肌病的影响作用
生化/生理作用
尿石素A是一种具有抗增殖和抗氧化活性的天然产物。
尿石素A是一种具有抗增殖和抗氧化活性的天然产物。尿石素A是由一些坚果和水果中的多酚代谢形成的，尤其是石榴。尿石素A已被证明可穿过血脑屏障，并可能对阿尔茨海默病具有神经保护作用。
尿石素A是研究最为充分的尿石素，具有抗炎和抗肥胖效用。也可抑制结肠癌、前列腺癌和膀胱癌等多种癌症的发生发展，作用机制是下调多种癌基因，包括哺乳动物雷帕霉素靶蛋白(mTOR)和Kirsten大鼠肉瘤病毒癌基因(K-Ras)，并上调肿瘤抑制基因，包括p53和表皮生长因子受体(EGFR)，从而影响多条肿瘤信号通路。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Antonio González-Sarrías et al.
European journal of nutrition, 56(2), 831-841 (2015-12-19)
Urolithins, metabolites produced by the gut microbiota from ellagic acid, have been acknowledged with cancer chemopreventive activity. Although urolithin A (Uro-A) has been reported to be the most active one, 10-50 % of humans can also produce the isomer isourolithin A
Sheng-Long Ding et al.
Journal of inflammation (London, England), 17, 13-13 (2020-03-27)
Osteoarthritis (OA) is characterized by inflammation and extracellular matrix (ECM) degradation and is one of the most common chronic degenerative joint diseases that causes pain and disability in adults. Urolithin A (UA) has been widely reported for its anti-inflammatory properties
Gadah Albasher et al.
Saudi journal of biological sciences, 29(2), 1210-1220 (2022-03-05)
This study examined the cardiac anti-cardiomyopathy (DC) protective effect of urolithin A in streptozotocin (STZ)-treated rats and investigated if this protection involves activation of SIRT1 signaling. Diabetes was induced first STZ (65 mg/kg, i.p.) before starting the experiments. Adult male rats
Tao Yuan et al.
ACS chemical neuroscience, 7(1), 26-33 (2015-11-13)
Pomegranate shows neuroprotective effects against Alzheimer's disease (AD) in several reported animal studies. However, whether its constituent ellagitannins and/or their physiologically relevant gut microbiota-derived metabolites, namely, urolithins (6H-dibenzo[b,d]pyran-6-one derivatives), are the responsible bioactive constituents is unknown. Therefore, from a pomegranate
Abdulaziz Musa Alzahrani et al.
International journal of molecular sciences, 22(11) (2021-06-03)
Leukemia is persistently a significant cause of illness and mortality worldwide. Urolithins, metabolites of ellagic acid and ellagitannins produced by gut microbiota, showed better bioactive compounds liable for the health benefits exerted by ellagic acid and ellagitannins containing pomegranate and
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