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安全信息

SML1785

Sigma-Aldrich

Landiolol hydrochloride

≥98% (HPLC)

别名:

4-[(2S)-2-Hydroxy-3-[[2-[(4-morpholinylcarbonyl)amino]ethyl]amino]propoxy]-benzenepropanoic acid [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl ester hydrochloride, 4-[2-Hydroxy-3-[[2-[(4-morpholinylcarbonyl)amino]ethyl]amino]propoxy]-benzenepropanoic acid [S-(R*,R*)]-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl ester hydrochloride, ONO 1101, ONO-1101

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About This Item

经验公式（希尔记法）:
C25H39N3O8 · HCl
CAS号:
144481-98-1
分子量:
546.05
MDL编号:
MFCD01937430
UNSPSC代码:
12352200
PubChem化学物质编号:
329826064
NACRES:
NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

H2O: 25 mg/mL, clear

储存温度

2-8°C

SMILES字符串

CC1(C)OC[C@@H](COC(CCC2=CC=C(OC[C@@H](O)CNCCNC(N3CCOCC3)=O)C=C2)=O)O1.[H]Cl

InChI

1S/C25H39N3O8.ClH/c1-25(2)35-18-22(36-25)17-34-23(30)8-5-19-3-6-21(7-4-19)33-16-20(29)15-26-9-10-27-24(31)28-11-13-32-14-12-28;/h3-4,6-7,20,22,26,29H,5,8-18H2,1-2H3,(H,27,31);1H/t20-,22+;/m0./s1

InChI key

DLPGJHSONYLBKP-IKGOIYPNSA-N

生化/生理作用

Landiolol is an ultra-short acting cardioselective β-adrenoceptor antagonist the exhibit β1-selectivity. New data shows that landiolol lacks pharmacochaperoning activity.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319

危险分类

Eye Irrit. 2 - Skin Irrit. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
106M4718V

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Shahrooz Nasrollahi-Shirazi et al.
The Journal of pharmacology and experimental therapeutics, 359(1), 73-81 (2016-07-28)
Blockage of β1-adrenergic receptors is one of the most effective treatments in cardiovascular medicine. Esmolol was introduced some three decades ago as a short-acting β1-selective antagonist. Landiolol is a more recent addition. Here we compared the two compounds for their
Shigeki Kobayashi et al.
PloS one, 10(1), e0114314-e0114314 (2015-01-24)
The purpose of this study was to investigate whether adding a low-dose β1-blocker to milrinone improves cardiac function in failing cardiomyocytes and the underlying cardioprotective mechanism. The molecular mechanism underlying how the combination of low-dose β1-blocker and milrinone affects intracellular
Yoshiyasu Ogura et al.
Life sciences, 118(2), 347-356 (2014-05-23)
Endothelin (ET)-1 is the best known potent vasoconstrictor and has been implicated in pathogenesis of sepsis-associated acute kidney injury (AKI) in human or lipopolysaccharide (LPS)-induced AKI in animal models. We have previously shown that ET-1 is highly up-regulated in renal

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