推荐产品
产品名称
BAY-876, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 25 mg/mL, clear
储存温度
2-8°C
SMILES字符串
FC1=CC=C2C(N=C(C(N)=O)C=C2C(NC3=C(C)N(CC4=CC=C(C#N)C=C4)N=C3C(F)(F)F)=O)=C1
InChI
1S/C24H16F4N6O2/c1-12-20(21(24(26,27)28)33-34(12)11-14-4-2-13(10-29)3-5-14)32-23(36)17-9-19(22(30)35)31-18-8-15(25)6-7-16(17)18/h2-9H,11H2,1H3,(H2,30,35)(H,32,36)
InChI key
BKLJDIJJOOQUFG-UHFFFAOYSA-N
1 of 4
此商品 | SML1780 | SML2384 | SML1276 |
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| Quality Level 100 | Quality Level - | Quality Level - | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 25 mg/mL, clear | solubility DMSO: 20 mg/mL, clear | solubility DMSO: 2 mg/mL, clear | solubility DMSO: 10 mg/mL, clear |
| color white to beige | color white to beige | color white to beige | color white to beige |
生化/生理作用
BAY-588是葡萄糖转运蛋白GLUT1的强效、高选择性、细胞可渗透的抑制剂。它的体外IC50值为2 nM，并且可抑制Hela-MaTu细胞摄取葡萄糖，IC50值为3.2 nM。BAY-876对GLUT1的选择性至少是GLUT2、GLUT3、GLUT4以及一种18种激酶和68种蛋白质组合的130倍。有关完整表征的详细信息，请访问结构基因组学联盟（SGC）网站上的 BAY-876 探针摘要。
BAY-588是活性探针BAY-876的阴性对照品。BAY-588可从Sigma购买。要了解更多信息并购买BAY-588，请单击此处。
想要了解用于蛋白质靶标的其他SGC化学探针，请访问sigma.com/sgc
BAY-588是活性探针BAY-876的阴性对照品。BAY-588可从Sigma购买。要了解更多信息并购买BAY-588，请单击此处。
想要了解用于蛋白质靶标的其他SGC化学探针，请访问sigma.com/sgc
葡萄糖转运蛋白GLUT1的强效、高选择性、细胞可渗透的抑制剂
特点和优势
BAY-876是一种化学探针，可通过与Structural Genomics Consortium (SGC) 的合作而获得。想要了解更多信息并查看其他SGC化学探针，请访问sigma.com/SGC。
这种化合物是氧化一氮和细胞压力研究的特色产品。点击此处发现更多特色氧化一氮和细胞压力产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
推荐产品
BAY-588是一种阴性对照品，可从Sigma购买。要了解更多信息并购买BAY-588， 请单击此处 。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Roman V Uzhachenko et al.
Cell reports, 35(1), 108944-108944 (2021-04-08)
Inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6i) delay progression of metastatic breast cancer. However, complete responses are uncommon and tumors eventually relapse. Here, we show that CDK4/6i can enhance efficacy of T cell-based therapies, such as adoptive T cell transfer or
Xiaoguang Liu et al.
Nature cell biology, 22(4), 476-486 (2020-04-02)
SLC7A11-mediated cystine uptake is critical for maintaining redox balance and cell survival. Here we show that this comes at a significant cost for cancer cells with high levels of SLC7A11. Actively importing cystine is potentially toxic due to its low
Yilei Zhang et al.
Cancer research, 80(11), 2243-2256 (2020-04-11)
Epigenetic regulation of gene transcription has been shown to coordinate with nutrient availability, yet the mechanisms underlying this coordination remain incompletely understood. Here, we show that glucose starvation suppresses histone 2A K119 monoubiquitination (H2Aub), a histone modification that correlates with
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