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质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 20 mg/mL, clear
储存温度
room temp
SMILES字符串
[S](=O)(=O)(NC5CCCCC5)c1cc2c(cc1)c3c(cc(cc3)[S](=O)(=O)NC4CCCCC4)C2N=O
InChI
1S/C25H31N3O5S2/c29-26-25-23-15-19(34(30,31)27-17-7-3-1-4-8-17)11-13-21(23)22-14-12-20(16-24(22)25)35(32,33)28-18-9-5-2-6-10-18/h11-18,25,27-28H,1-10H2
InChI key
OYLSCKVHQYAZEE-UHFFFAOYSA-N
生化/生理作用
FIN56 是铁死亡的特异性诱导因子。
FIN56 是铁死亡的特异性诱导因子，铁死亡是一种非凋亡形式的细胞死亡，其特点是脂质过氧化产物和致命的活性氧（ROS）的铁依赖性累积。FIN56 的 EC50 值为 240 nM，并且人们认为其通过两条独立的途径起作用。 第一条途径需要乙酰辅酶 A 羧化酶（ACC）的酶促活性，并导致谷胱甘肽过氧化物酶 4（GPX4）降解，该酶通过减少脂质氢过氧化物而作为铁死亡的负调节剂。 第二条途径涉及 FIN56 结合并激活鲨烯合酶，从而导致辅酶 Q10 耗竭。
铁死亡诱导剂 56（FIN56）是 3 类铁死亡诱导剂的成员。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Unsolved mysteries: How does lipid peroxidation cause ferroptosis?.
Feng H and Stockwell BR
PLoS Biology, 16(5), e2006203-e2006203 (2018)
Xingzhe Ma et al.
Cell metabolism, 33(5), 1001-1012 (2021-03-11)
Understanding the mechanisms underlying how T cells become dysfunctional in a tumor microenvironment (TME) will greatly benefit cancer immunotherapy. We found that increased CD36 expression in tumor-infiltrating CD8+ T cells, which was induced by TME cholesterol, was associated with tumor progression and
Po-Han Chen et al.
Cell death and differentiation, 27(3), 1008-1022 (2019-07-20)
Ferroptosis is a specialized iron-dependent cell death that is associated with lethal lipid peroxidation. Modulation of ferroptosis may have therapeutic potential since it has been implicated in various human diseases as well as potential antitumor activities. However, much remains unknown
Ye Zhu et al.
Nature cell biology, 26(4), 542-551 (2024-03-08)
β-Propeller protein-associated neurodegeneration (BPAN) is a rare X-linked dominant disease, one of several conditions that manifest with neurodegeneration and brain iron accumulation. Mutations in the WD repeat domain 45 (WDR45) gene encoding WIPI4 lead to loss of function in BPAN
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